核小体结构

在真核生物中，DNA按左手手征性的方式，缠绕在组蛋白八聚体的周围，形成稳定的核小体结构。

In all eukaryotes , DNA wraps around a histone octamer in a left-handed way , forming a stable nucleosome structure .

依赖于ATP的染色质改构复合物对核小体结构的调整是基因转录的必要前提。

It is necessary for facilitating transcription to disrupt nucleosome structure by the ATP-dependent nucleosome remodeling complexes .

在真核细胞中，所有的基因组DNA与高度进化保守的碱性蛋白&组蛋白以及多种组蛋白相关染色质因子组装构成核小体结构，重复此单元而形成染色质结构。

In eukaryotic cells , all genomic DNA with a high degree of evolutionary conservation of basic protein & histone and histone-related chromatin assembly factors constitute a nucleosome structure ; the repetition of this element forms chromatin structure .

利用这种新型工具，Luger和他的同事进行了X射线晶体学和生物物理学研究，来看甲基化怎样影响染色质和核小体结构。

With this new set of tools , Luger and her colleagues did x-ray crystallographic and biophysical studies to see how methylation affects the structure of chromatin and nucleosomes .

核小体结构的一般特性似乎在所有的真核生物中都很相似。

The general features of nucleosome structure appear to be similar in all eukaryotes .

钠离子浓度对核小体纤维结构影响的MonteCarlo模拟

Monte Carlo simulation of chromatin fiber conformation affected by ionic strength

在真核细胞中，核小体的核心结构组蛋白被DNA紧密缠绕，但是这种紧密的结合有时也可能变得松散，以利于其他蛋白与DNA的结合。

Histone and DNA bind together to form the nucleosome , but this tight binding can loose at some times to facilitate other proteins to interact with DNA .

细胞核是具有高度组织性的结构，它有序清晰的排列成许多膜缺失的核小体，这种结构区划方式对于基本分子复合物来说被认为是最重要，最有效的形式。

The cell nucleus is a highly organized structure . It is arranged into distinct membrane-lacking nuclear bodies . This compartmentalization is thought to represent the most efficient organization of essential molecular complexes .

研究人员怀着了解两种不同的甲基化标记怎样影响核小体和染色质结构的目的开始工作。

The researchers began their work with the goal of learning how two different methylation marks affect the overall structure of nucleosomes and chromatin .

结论：在痘病毒感染胞核内观察到四种核内包含体和核小体，这些特殊结构的形成与胞核功能活跃有关。

Conclusion : There are four kinds of intranuclear inclusion and nuclear bodies in nucleus of cells infected by poxvirus ; their formation may be related to active condition of nuclear functions .

核小体动力学主要研究DNA与组蛋白的相互作用下核小体受力、结构形成过程，是蛋白质组研究计划的核心研究内容之一。

Nucleosome dynamics , one of the core areas of histone protein research projects , is largely concerned with the interaction between DNA and histone octamer and properties of the formation of nucleosome complex .