条件性位置偏爱实验

视频跟踪-计算机自动分析的小鼠条件性位置偏爱实验系统的构建

Establishment of computer based video tracking conditioned place preference experiment system in mice

微机全自动程序控制的条件性位置偏爱实验系统

Conditioned place preference experiment system controlled by Microcomputer

方法：采用条件性位置偏爱实验反映DHE的精神依赖性。

Methods : The conditioned place preference paradigm was used to evaluate the rewarding effect of DHE .

采用条件性位置偏爱实验方法对盐水组、吗啡组和吗啡加舒必利（5、10、20mg／kg）三个组的50只大鼠进行观察。

Conditioned place preference was used to investigate fifty rats , which were assigned into five groups and received saline , morphine , morphine plus sulpiride 5 mg / kg , morphine plus sulpiride 10 mg / kg , morphine plus sulpiride 20 mg / kg respectively .

结果条件性位置偏爱实验自第6d后MD组大鼠由C1进入C2时间平均（084±050）min，与对照组（2.40±1.10）min比较差异有显著性（P<0.05）；

Results The mean time of MD rats entering from C1 to C2 was ( 0.84 ± 0 50 ) min after 6 days ' conditioned place preference training , shorter than that of the control group [ ( 2.40 ± 1 10 ) min , P < 0.05 ] .

条件性位置偏爱实验建立吗啡精神依赖模型。

Conditioned place preference ( CPP ) was used to establish the morphine psychical dependence .

条件性位置偏爱实验装置为大鼠位置偏爱箱，由黑、白盒构成。

Experimental devices of CPP are place preference boxes of rats , which are comprised of black and white boxes .

方法采用剂量递增吗啡依赖模型空白对照法及吗啡依赖动物自身对照方法，评价作者建立的计算机控制的条件性位置偏爱实验系统。

METHODS Rat model for dependence was developed by increasing dosage and self compared ( s.c. morphine ), then the CPP effects in this system were evaluated .

利用条件性位置偏爱实验研究钙拮抗剂粉防己碱对小鼠吗啡奖赏效应的影响。

The effect of tetrandrine ( Tet ), a calcium channel antagonist , on the rewarding property of morphine ( Mor ) was studied using a conditioned place preference paradigm in mice .

结果：在条件性位置偏爱实验中，单纯给药组与毁损给药组、单纯毁损组、对照组相比较存在显著差异（P<0.05）。

Results : In CPP test , there were significant differences in CPP between the morphine alone group and other 3 groups , impaired alone group , impaired plus morphine group , and control group ( P < 0.05 ) .