昂丹司琼

对照组于化疗前单用盐酸昂丹司琼（8mg）静脉注射。

The patients in the control group received a single intravenous dose of Ondansetron Hydrochloride ( 8mg ) before chemotherapy .

昂丹司琼（ondansetron）为一种强效、高选择性的5-HT3受体拮抗剂，主要用于预防和治疗抗肿瘤化疗和放疗所引起的恶心和呕吐。

Ondansetron is a potent , highly selective 5-HT_ ( 3 ) receptor antagonist , It is used for the prevention and management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy .

但完全控制率托烷司琼优于昂丹司琼（P<0.05）。

Tropisetron was superior to ondansetron in the complete control rate ( P < 0.05 ) .

目的：本课题研究设计采用现代药物制剂新技术、新材料、新方法，将盐酸昂丹司琼研制成智能化温敏型凝胶控释鼻黏膜给药系统，并建立质量控制和评价方法。

The effect of buccal mucosa in different regions on penetration and absorption of drugs , various and quality evaluation methods of buccal mucosa drug delivery system are introduced .