无效造血

背景和目的：骨髓增生异常综合征（MDS）包括一组以血细胞发育异常和无效造血为特征的造血干细胞疾病，有很高的发生急性髓系白血病（AML）转化的危险性。

Background and objective : Myelodysplastic syndromes ( MDS ) is a heterogeneous group of hematopoietic stem cell disorders characterized by marrow cell dysplasia and ineffective hematopoiesis , with a high risk of transformation into acute myeloid leukemia ( AML ) .

结论：MDS患者骨髓细胞的凋亡受多因素的调节，TNF-α与Fas／FasL系统介导的凋亡以及机体对其调控的失常参与了MDS骨髓无效造血的病理生理过程。

Conclusions : apoptosis of bone marrow cells was affected by a lot of factors in MDS , the apoptosis induced by TNF - α and Fas / FasL system can involve in the ineffective hematopoiesis in MDS .

背景骨髓增生异常综合征（MDS）包括一组异质性的克隆性造血干细胞疾病，其特征是无效造血和分化异常以及有向急性髓性白血病转化的风险。

Background : Myelodysplastic syndrome ( MDS ) encompasses a heterogeneous group of clonal hematopoietic stem-cell disorders , characterized by ineffective and dysplastic hematopoietic differentiation and variable risk progressed to acute myeloid leukemia .

结论网织红细胞细胞多参数测定提示，地中海贫血时患者网织红细胞细胞中未成熟细胞所占比例增加可能是导致无效造血的主要原因之一；

Conclusion The increased proportion of immature reticulocytes in thalassemia patients might be one of the main reasons of ineffective erythropoiesis .