抗精神病药物

常用抗精神病药物与血清ALT的相关性研究

The relevance of research of antipsychotic drugs commonly used and serum ALT

研究表明：典型抗精神病药物治疗精神分裂症的临床效应与其阻断中枢多巴胺受体（DR）有关。

Many studies showed that the clinical effect of typical antipsychotic drugs for schizophrenia is due to their blockage of dopamine receptor ( DR ) .

57例服用与30例未服用抗精神病药物的患者的异常淋巴细胞差异无显著性（P＞0.05）。

No significant difference in percentage of atypical lymphocytes was observed between 30 patients with and 57 patients without neuroleptics treatment .

目的：探讨常用抗精神病药物与ECG异常的关系。

Objective : To explore the relationship between the usual antipsychotics and influences of ECG .

这是FDA首次批准的用于青少年精神疾病的非典型抗精神病药物。

This is the first FDA approval of an atypical antipsychotic drug to treat either disorder in these age groups .

结论非经典抗精神病药物存在可能导致QTc延长的危险。

Conclusion : Atypical antipsychotics have potential risk to cause QTc elongation .

5-HT（2c）受体基因多态性与抗精神病药物疗效的关联分析

Association of 5-HT_ ( 2c ) receptor genes polymorphism with therapeutic response of atypical antipsychotics for treating first-episode schizophrenia

抗精神病药物致体重增加与5羟色胺2C受体基因启动子区多态性的关系

Association of antipsychotic agent-induced weight gain with a polymorphism of the promotor region of the 5-HT 2C receptor gene

背景5-羟色胺2A受体基因已经证实为精神分裂症的候选易感基因，因为阐明其作为非典型抗精神病药物重要作用靶点减轻阴性症状已引起业界倍加关注。

Background 5-hydroxytryptamine 2A receptor ( 5-HT2A ) gene has been regarded as a candidate gene for susceptibility to schizophrenia .

方法本文对照研究了抗精神病药物对乙肝病毒感染（HBV）、未感染和曾感染但已恢复的精神分裂症患者肝功能的影响。

Method So we made a comparative study on liver function during antipsychotic medications among patients with HBV infection , without HBV infection and patients having recovered from HBV infection .

应用非典型性抗精神病药物和甘氨酸位点激动剂可以改善PCP诱导的不动增加，但典型性抗精神病药物无效。

The enhanced effect of PCP was attenuated by atypical antipsychotics and glycine agonist , but not by the typical antipsychotics .

IL一2水平的降低也许可以作为抗精神病药物（尤其是氯氮平）疗效的一个参考指标。

The decreased IL-2 levels of plasma in initial remission may be considered as a reference parameter for the effect of antipsychotic agent ( especially clozapine ) on the immune alternation .

抗精神病药物导致的迟发性锥体外系综合征（TES）由迟发性运动障碍（TD）发展而来。

Neuroleptic - associated tardive extrapyramidal syndrome ( TES ) has been developed in the base of the tardive dyskinesia ( TD ) .

方法应用Meta分析对22项研究维思通与其它抗精神病药物治疗精神分裂症阴性症状进行再分析，评价其综合显著性差异和效应大小。

Methods 22 studies that compare effects differences in treatment of negative symptom between risperidone and other antipsychotics was analysed by meta analysis in comprehensive test and effect side .

抗精神病药物治疗后血浆中AA和DHA浓度均降低。提示抗精神病药物对血浆中AA和DHA浓度有降低效应，原因可能是抑制了脂肪酸的分解代谢。

Antipsychotic drugs can decrease the concentrations of AA and DHA in the plasma of patients with schizophrenia , which may be due to the inhibition of PUFA catabolism .

目的：对通心络治疗抗精神病药物所致心电图ST-T改变的疗效和安全性作出评价。

Objective : To evaluate the therapeutic efficacy and safety of Tong Xing Luo in the treatment of ECG ST-T changes Caused by antipsychotic drugs .

视觉诱发电位使用肌电诱发电位仪，在20～25℃安静屏蔽室内检查，检查前3d内禁服中枢镇静药和抗精神病药物。

Electromyographic evoked potential meter was used for examination of visual evoked potential at 20 to 25 ℃ in a quiet shield room , and they were forbidden to taken any drug for central sedation and antipsychotic drugs within the 3 days before examination .

本报道详细描述了慢性精神分裂症患者在服用抗精神病药物期间服用抗结核病药物后出现安定药恶性综合症（NMS）的症状。

In this report , we describe a patient with chronic schizophrenia who developed probable NMS following the addition of antituberculotic drugs to his antipsychotic regimen .

5-HT（2C）受体基因多态性与首发精神分裂症患者抗精神病药物疗效的关联分析4种非典型抗精神病药物对精神分裂症患者血糖及血脂代谢的影响

Association of 5-TH_ ( 2C ) Receptor Genes Polymorphism with Therapeutic Response to Antipsychotic Drugs in First-episode Schizophrenia ; Effects on Lipid and Glucose Metabolism among Four Different Atypical Antipsychotics Agents

探讨首次治疗精神分裂症患者抗精神病药物（APS）治疗所致体重增加、腹部脂肪沉积、代谢改变及其与血瘦素水平的关系。

To assess the effects of antipsychotic agents therapy on weight gain and abdominal fat deposition and distribution , on circulating leptin and insulin secretion in previously untreated patients with schizophrenia .

目的比较第一代抗精神病药物（FGA）和第二代抗精神病药物（SGA）的临床疗效及不良反应。

Objective To compare the clinical efficacy and adverse reactions of first generation antipsychotics ( FGA ) and second generation antipsychotics ( SGA ) .

目的探讨瘦素基因启动子区-2548G/A功能多态性是否与首次治疗精神分裂症患者的抗精神病药物（APS）急性期治疗导致的体重增加相关。

Objective To investigate whether the - 2548G / A functional polymorphism in promoter region of leptin gene influencing weight gain following antipsychotic agents ( APS ) acute treatment in schizophrenic patients .

本文采用放射受体分析（RRA）法，检测了50例精神病患者血清中抗精神病药物的浓度，并与氯丙嗪（CPZ）放射免疫分析（RIA）法作了平行对照。

Serum antipsychotic drug in 50 psychosis cases were measured by radioreceptor assay ( RRA ) and the values were compared in parallel with that by radioimmunoassay ( RIA ) .

由于临床还没有可以取代Olanzapine的药物出现，故Olanzapine的应用还是很广泛，于是在临床上寻找与Olanzapine联合用的，能改善抗精神病药物诱导的脂代谢异常的药物就显得很是迫切。

Now there is no drugs could replace Olanzapine in the clinical , therefore finding the drug which combined with Olanzapine can improve antipsychotic-induced abnormal lipid metabolism drugs becomes very urgent .

方法对住院首发精神分裂症和分裂样精神病患者服用不同的抗精神病药物，入院时、3个月和1a后测量体重及Quetelet指数的变化。

Method The first onset schizophrenics and schizoid disorders take different antipsychotic drugs , the weight and Quetelet index were measured at the end of 3 months and 1 year respectively .

条件性恐惧应激实验是一种精神性应激实验，长期给予PCP可以增强这种应激反应，而甘氨酸位点激动剂可以改善这种反应，但典型性和非典型性抗精神病药物无效。

In the conditioned fear stress ( CFS ) test , a psychological stress test , repeated PCP treatment enhanced the CFS response . Glycine agonists but not typical and atypical antipsychotics attenuated the enhancement induced by PCP .

结果两组患者在服用抗精神病药物8w内，白细胞总数均呈不断下降趋势，但第4w、8w间白细胞总数比较无显著性差异（P0.05）；

Results The total numbers of white blood cells of all the subjects exhibited continuous downtrend during 8 week treatment and no significant difference between the 4 ~ ( th ) and 8 ~ ( th ) week ( P0.05 );

方法：采用前瞻性设计的方法，对连续入院的129例精神分裂症病人，分别在6周的单一抗精神病药物治疗前后使用BPRS，SANS，SAPS及自编问卷进行调查和评估。

Method : Based on prospective design , 129 cases of consecutively admitted schizophrenic patients were investigated and assessed with BPRS , SAPS , SANS and a self made questionnaire before and after 6 weeks of one antipsychotic drug treatment .

辉瑞还因Bextra以及抗精神病药物Geodon，抗生素Zyvox和抗癫痫病药物Lyrica而面临民事指控。

Pfizer also faced civil charges over Bextra as well as an anti-psychotic drug , Geodon ; an antibiotic , Zyvox ; and an anti-epilepsy drug , Lyrica .

目的：探讨女性精神分裂症患者血清白细胞介素6（IL-6）、可溶性白细胞介素6受体（sIL-6R）治疗前后变化及其与抗精神病药物氯氮平血清水平的关系。

AIM : To investigate the changes of serum levels of interleukin 6 ( IL 6 ) and soluble interleukin 6 receptor ( sIL 6R ) in female schizophrenic patients before and after treatment , and their relationships with serum level of the antipsychotic drug , clozapine .