恶性黑素瘤

三氧化二砷对鼠恶性黑素瘤B（16）细胞凋亡的影响

The effect of arsenic trioxide on apoptosis of melanoma B_ ( 16 ) cells

TNF相关的凋亡诱导配体及其受体与恶性黑素瘤的凋亡

TNF Related Apoptosis Induced Ligand and the Receptor in the Apoptosis of Malignant Melanoma

运用cDNA芯片技术对恶性黑素瘤相关基因的研究

Study on Melanoma Gene Expression Profile by cDNA Microarray

恶性黑素瘤和普通痣细胞痣组织中双链RNA依赖的蛋白激酶的表达

Expression of Double - stranded RNA - dependent Protein Kinase in Malignant Melanoma and Ordinary Nevi

恶性黑素瘤（MM）是一种罕见且发病率正在不断增加的皮肤癌症。

Malignant melanoma ( MM ) is one of the rare skin cancers with an increasing incidence rate .

SEA基因修饰抑制小鼠恶性黑素瘤B16细胞肺转移

Suppressive effects of SEA gene transduction on lung metastasis of murine melanoma B16 cells

目的通过对恶性黑素瘤（MM）可能致病相关基因及MM致病相关信号转导途径的研究，探讨本病的发病机制，以期为今后进一步寻找诊断和治疗本病的新途径打下理论和实验基础。

Objective To investigate the probable related genes and ERK signal transduction pathway in the pathogenesis of malignant melanoma ( MM ) .

过继免疫治疗，即给患者输注抗肿瘤免疫效应细胞的方法，是治疗恶性黑素瘤（malignantMelanoma，MM）的一种重要的免疫策略。

Adoptive immunotherapy , i.e. the method for inducing anti-tumor immune effector cells , is an important immune strategy to treat malignant melanoma .

RNAi沉默WT1基因逆转恶性黑素瘤细胞耐药性的研究

RNAi Silencing of the WT1 Gene Reverses Drug Resistance of Malignant Melanoma

恶性黑素瘤细胞周期素D3及增殖细胞核抗原的表达

Expression of Cyclin D3 and PCNA in Cutaneous Malignant Melanoma

酪氨酸酶相关蛋白1（tyrosinaserelatedprotein1，TRP-1）是黑素细胞和恶性黑素瘤细胞中含量最丰富的糖蛋白，其基因是第一个克隆成功的色素基因。

TRP-1 ( tyrosinase related protein 1 , TRP-1 ) or glycoprotein 75 is the most abundant glycoprotein in melanocytes .

内皮素受体B作为一种重要的内皮素家族受体，在恶性黑素瘤中与其配体内皮素-1和内皮素-3结合而被激活。

The endothelin B receptor ( ETBR ), an important receptor of the endothelin ( ET ) family , can be activated by its ligands , ET-1 and ET-3 , in malignant melanoma ( MM ) .

越来越多证据表明针对性抑制Bcl-2，可促进细胞凋亡，提高肿瘤细胞对化疗药物的敏感性，从而逆转恶性黑素瘤的耐药性。

There is growing evidence that reduction of Bcl-2 expression can induce apoptosis , enhance the chemosensitivity of cells and help to overcome chemoresistance in melanoma .

血清MIA检测在恶性黑素瘤诊断中的临床价值

The clinical value of quantitated serum levels of MIA protein in diagnosis of malignant melanomas

结论：消炎痛能抑制人恶性黑素瘤Libr细胞系的生长，诱导细胞凋亡。

Conclusion Antinfan could inhibit the cell growth and induce apoptosis in human melanoma Libr cell line .

目的：评价消炎痛对人恶性黑素瘤Libr细胞系的抑制作用。

Objective To assess the inhibition of cell growth in human melanoma Libr cell line by antinfan .

动物实验研究表明，Bcl-2相关蛋白的变化可显著改变药物敏感性，与恶性黑素瘤耐药有关。

In experimental models , it is found that mutations or altered expression of Bcl-2-related proteins can drastically alter drug sensitivity and are associated with multidrug resistance in human melanoma .

目的研究CD44V6在鳞状细胞癌、基底细胞癌和恶性黑素瘤的表达。

Objective To study the expression of CD44V6 in human epidermal tumours and malignant melanoma .

恶性黑素瘤和色素痣中PI3K、AKT、NRAS和ERK的表达及其意义

Expressions of pi3k , akt , nras and ERK protein in malignant melanoma and nevus pigmentosus and their significance

皮肤恶性黑素瘤（CMM）因其易转移、对细胞毒药物耐受等特点而被认为是最具侵袭性和致死率最高的肿瘤之一。

Cutaneous malignant melanoma ( CMM ) is considered one of the most aggressive and lethal malignancies because of its propensity to metastasize and resistance to cytotoxic agents .

TRP-1在正常黑素细胞及恶性黑素瘤细胞中的作用研究

Investigation of the Roles Play by TRP-1 in Melanocytes and Malignant Melanoma Cells

目的：检测黑素细胞痣及不同生长阶段恶性黑素瘤（简称恶黑）中血管内皮生长因子（VEGF）及β-连环蛋白（catenin）的表达，以探寻它们之间的关系及其临床病理意义。

Objective : To examine the expression of VEGF and β - catenin in different growing stages of benign melanocytic nevi and malignant melanomas , for exploring their relationship and clinicopathologic significance .

目的探讨乙酰肝素酶mRNA和蛋白在恶性黑素瘤皮损及A375细胞株中的表达及意义。

Objective To investigate the expression of heparinase mRNA and protein in malignant melanoma ( MM ) lesions as well as cell line and its significance .

TRP-1反义核酸抑制恶性黑素瘤细胞增殖的体外及体内研究

The Inhibition of Antisense TRPl in the Proliferation of Malignant Melanoma Cells in vivo and in vitro

三氧化二砷对小鼠恶性黑素瘤细胞CloudmanS91的作用

Effects of Arsenic Trioxide on Mouse Cultured Melanoma Cloudman S91 Cells

结论PKR在恶性黑素瘤细胞增殖过程中具有重要作用。

Conclusion PKR may play an important role in the cellular proliferation of malignant melanoma .

方法免疫组化方法检测36例人恶性黑素瘤和30例色素痣组织中生存素、VEGF和PCNA蛋白表达。

Methods Tissue sections from 36 cases of MM and 30 pigmented nevi ( as control ) were examined with immunohistochemical technique and morphological quantitative analysis for the protein expressions of survivin , VEGF and PCNA .

结果：与色素痣比较，皮肤恶性黑素瘤中MMP-9表达较强（P<0.05），MMP-9/TIMP-1比值较高（P<0.05）。

Results : The expression of MMP - 9 and the MMP - 9 / TIMP - 1 ratio was higher in cutaneous malignant melanoma than that in nevus ( P < 0.05 ) .

应用抗人增殖细胞抗体Ki-67，以ABC法对15例恶性黑素瘤（MM）、17例后天性痣、18例先天性小痣及3例先天性巨痣进行标记染色。

Fifteen cases of malignant melanoma , 17 cases of acquired nevus , 18 cases of congenital small nevus , and 3 cases of congenital giant nevus were labeled with anti-human prolifera-tive cell antibody Ki-67 with ABC labeling method .

pU-VEGF-siRNA对裸鼠恶性黑素瘤生长影响的研究

In vivo studies on the role of pU-VEGF-siRNA in the growth of malignant melanoma