左乙拉西坦

目的观察新型抗疒间药物左乙拉西坦（LEV）联合治疗对成人颞叶癫疒间术后早发性癫疒间（APOS）的预防作用。

Objective To explore the effect of levetiracetam ( LEV ), a new type antiepileptic drug , as an addon therapy on acute postoperative seizures ( APOS ) in adults with refractory temporal epilepsy .

目的：研究左乙拉西坦的合成方法。

Objective : To study the synthesis of levetiracetam .

左乙拉西坦对慢性致痫大鼠海马神经元凋亡和Bcl-2及Bax表达的影响

Effect of Levetiracetam on Neuron Apoptosis and Bax and Bcl-2 Expression in Hippocampus of Chronic Epilepsy Rats

左乙拉西坦预防动物热性惊厥的实验研究

Study on Prophylaxis of Febrile Convulsion with Levetiracetam in Rats

武汉市左乙拉西坦治疗儿童癫痫多中心前瞻性临床研究

Multicenter prospective study of levetiracetam therapy for children 's epilepsy in Wuhan

左乙拉西坦组与丙戊酸钠组差异无统计学意义。

There were no significant differences between the levetiracetam and valproate groups .

左乙拉西坦是一种新型的抗癫痫药物，具有独特的抗癫痫机制和显著的药代动力学特征。

Levetiracetam is a pyrrolidone derivative with unique anti-epileptic mechanism and good pharmacokinetic characteristics .

左乙拉西坦添加治疗难治性癫癎的临床观察

Observation of Levetiracetam Add-on Therapy of Refractory Epilepsy

左乙拉西坦在非抗癫痫领域的应用进展

Headway of Levetiracetam in Non-application of Anti-epileptic

左乙拉西坦、苯妥英、卡马西平及丙戊酸对骨质影响的风险评估

Risk Factory Assessment of Levetiracetam , Phenytoin , Valproate and Carbamazepine Acting on Bone Metabolism

结论：目前证据表明，左乙拉西坦治疗儿童癫癎有效，但仍需更多实验数据支持。

CONCLUSIONS : The current evidence shows that levetiracetam therapy is effective for childhood epilepsy .

左乙拉西坦治疗小儿癫痫的疗效和安全性分析

A clinical observation for the efficacy and safety of levetiracetam in treatment of children with epilepsy

左乙拉西坦单药治疗各类癫癎的疗效治疗药物监测在抗癫痫药物中的作用

The Efficacy of Levetiracetam Monotherapy in Treating Epilepsy The use of therapeutic drug monitoring on antiepileptic drugs

本研究系统评价左乙拉西坦治疗儿童癫癎的有效性和安全性。

This study performed a systematic review to evaluate the effectiveness and safety of levetiracetam therapy for childhood epilepsy .

以（S）-2-氨基丁酰胺盐酸盐为手性源合成左乙拉西坦的工艺比较

Comparison on synthesis process of levetiracetam starting by use of ( S ) - 2-amino-butanamide hydrochloride as a chiral resource

本文对左乙拉西坦治疗头痛、疼痛性周围神经病、运动障碍及精神障碍等领域的研究做一综述。

Aim : To explore the characteristics of a group of movement disorders which showed primary symptom of freezing gait .

左乙拉西坦治疗相关副反应发生率与安慰剂组和奥卡西平两组差异无统计学意义。

The adverse effects in the levetiracetam therapy group were not significantly different from the placebo and the oxcarbazepine therapy groups .

筛选以2-溴代丁酸为起始原料，经氨解，酯化，酯胺解，拆分，环合五步反应制得左乙拉西坦。

Screening for2-bromo-butyric acid as the starting material , after ammonolysis , esterification , ester amine solution , split , five-step cyclization reaction Levetiracetam .

左乙拉西坦的确切抗癫痫机制尚不明，但与传统抗癫痫药物作用于离子通道或兴奋性、抑制性神经递质系统不同。

The precise mechanisms of its antiepileptic effect is unknown and does not appear to derive from any ion passage interaction with known mechanisms involved in inhibitory and excitable neurotransmission .