多巴胺能神经元

多巴胺能神经元在控制人体随意运动和调节姿势位置中起着关键作用。

Dopamine neurons play key roles in controlling voluntary movements and regulating body gestures .

目的：探讨大鼠中脑黑质多巴胺能神经元的衰老性变化规律，为进一步揭示黑质病变的病因提供客观依据。

AIM : To study the regularities of dopamine neurons in substantia nigra of middle brain with age increasing , and further provide objective evidence for revealing lesion of substantia nigra .

抗颤宁方对PD大鼠脂质过氧化及多巴胺能神经元的影响研究

Effect of Kang Chan Ning Fang on Peroxidation and DA Neuron Parkinson 's Disease Rat Model

大鼠PD模型多巴胺能神经元损毁与纹状体相关神经元内c-fos的表达

Parkinson Disease Models with 6-OHDA-lesioned Rats with Dopaminergic Neurons Loss and Proto oncogene c-fos Expression

RNA干扰α-突触核蛋白对多巴胺能神经元的影响及其机制

Effect and Its Mechanism of α - Synuclein Knockdown on Dopaminergic Neurons in Parkinson 's Disease in Vitro Model

试验表明，细菌脂多糖（LPS）能诱导多巴胺能神经元的炎症反应。

Experimentally , neuroinflammation of dopaminergic neurons can be evoked by lipopolysaccharides ( LPS ) exposure .

帕金森氏病（PD）是一种神经退行性疾病，其特征为黑质的多巴胺能神经元变性。

Parkinson 's disease ( PD ) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra .

大鼠黑质损毁后多巴胺能神经元形态及纹状体c-fos表达的变化

Changes of dopaminergic neuron morphology and expression of c-fos in corpusstriatum after rat substantia nigra lesion

α-synuclein片段NAC对多巴胺能神经元的神经变性作用

Neurodegenerative Effect of α - Synuclein Fragment-NAC on Dopaminergic Neurons

目的：建立脂多糖诱导的帕金森病（Parkinsondisease，PD）大鼠模型，研究脂多糖对黑质多巴胺能神经元的损毁作用。

Objective : To establish the rat Parkinson disease ( PD ) model induced with lipopolysaccharide ( LPS ) and study LPS-induced injury of dopaminergic neurons .

本研究结果表明，LPS导致多巴胺能神经元退行性变化，被激活的胶质细胞产生自由基，比如出现一氧化氮和过氧亚硝基阴离子是主要的神经毒性中介体。

Activated glial produce free radical such as NO and ONOO - appear to be the major mediators of neurotoxicity .

模型给药组与模型组相比TH免疫反应阳性多巴胺能神经元数目明显增加（P<0.01）。

The number of TH-IR positive neurons in the therapy group dramatically increased as compared with the model group ( P < 0.01 ) .

而HNG－E则为发生转化的神经干细胞系，但能在RA诱导下向多巴胺能神经元分化。

HNG-E cells were characterized as transformed neural stem cells , and can be differentiated into dopaminergic neurons by RA induction .

使用TUNEL法检测帕金森病小鼠模型多巴胺能神经元凋亡。

TUNEL technique was used to detect the apoptotic dopaminergic neurons in PD model of C57BL mice .

但是目前尚无有效方法将BMSCs诱导分化为多巴胺能神经元。

However , there were no effect methods of inducing BMSCs differentiating into dopaminergic neurons up to now .

KA诱发癫痫反复发作损伤大鼠空间学习记忆及中脑多巴胺能神经元

Spontaneous recurrent seizure induced by KA damages spatial learning and memory as well as dopaminergic neurons in rats

PD在病理学上以黑质致密部多巴胺能神经元选择性变性缺失为特点。

The pathology of PD can be attributed to the selective loss of dopaminergic ( DAergic ) neurons in the substantia nigra pars compacta ( SNPc ) .

烟碱对MPTP引起的C57BL/6小鼠黑质纹状体多巴胺能神经元损伤的保护作用

Nicotine Prevents MPTP-induced Depletion of Dopamine in the Striatum in C57BL / 6Mice

帕金森病（Parkinson'sdiseasePD）是一种以锥体外系黑质多巴胺能神经元进行性损害为主要病理表现的中枢神经系统退变性疾病。

Parkinson 's disease ( PD ) is a neurodegenerative disorder in the central nerve system which characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta ( SNpc ) .

这些作用伴随黑质多巴胺能神经元的丢失，但中缝核的细胞数量和形态以及5－羟色胺（5－HT）免疫组织化学反应与对照组相同。

These effects were accompanied by loss of nigral dopaminergic cells but not of raphe cell bodies or 5 HT immunoreactivity .

结论GDNF能促进PD模型大鼠黑质内神经元前体细胞向多巴胺能神经元方向分化。

? Conclusion GDNF might be able to promote the neuronal precursors in the SN of PD rats to differentiate into DA neurons .

姜黄素对6-OHDA诱导的多巴胺能神经元损伤的保护作用

Protective Effects of Curcumin Against 6-OHDA-induced Dopaminergic Neurodegeneration in Rat and MES 23.5 Cells

结论DBS使纹状体多巴胺能神经元递质合成与分泌发生了改变。

Conclusions The synthesis and excretion of neurotransmitter of dopaminergic neuron in brain striatum had a change during DBS-STN .

低氧促进P19细胞向多巴胺能神经元分化

Hypoxia promotes the differentiation of P19 embryonal carcinoma cells into dopaminergic neurons

目的体外诱导胚胎干细胞（ES细胞）定向分化为多巴胺能神经元并促进其长期存活和特性维持。

Objective To induce the embryonic stem cells ( ES cells ) to be dopaminergic neurons and to promote the survival and maintainence of these neurons .

目的探讨颞叶癫痫反复发作（Spontaneousrecurrentseizure，SRS）对大鼠空间学习记忆影响及中脑内多巴胺能神经元变化。

Objective To explore the effects of Spontaneous recurrent seizure ( SRS ) on Spatial learning memory and dopaminergic neurons of the midbrain in KA treated rats .

第一章：FLZ通过抑制Src酪氨酸激酶减弱神经炎症并保护多巴胺能神经元。

Chapter I : FLZ attenuats neuroinflammation and protects dopaminergic neurons through inhibiting Src tyrosine kinase .

损毁丘脑底核阻止6-OHDA对大鼠多巴胺能神经元的损伤作用

Prevention of neurotoxin damage of 6 - OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions

共聚物-1致敏T淋巴细胞保护MPTP帕金森病模型小鼠黑质多巴胺能神经元

T Lymphocytes from Copolymer-1 Immunized Mice Protect Dopaminergic Neurons in the MPTP Mouse Model of Parkinson 's Disease

目的明确6-羟基多巴（6-OHDA）致多巴胺能神经元凋亡与氧化应激的关系，以及外源性超氧化物歧化酶（SOD）对多巴胺能神经元凋亡的保护作用。

Objective To define oxidative stress and antagonistic action of the exogenous SOD in the apoptosis of the rat midbrain dopaminergic neuronal induced by 6-OHDA .