四氢叶酸

人类5,10-亚甲基四氢叶酸还原酶N端部分的克隆和表达

Cloning and expression of N terminal human 5 , 10-methylenetetrahydrofolate reductase code gene

重组人诱导型一氧化氮合酶在V（79）细胞中的表达及四氢叶酸对其活性的影响

Expression of human inducible nitric oxide synthase in fibroblast cell line V_ ( 79 ) and effects of H_ ( 4 ) Bon iNOS activity

（6S）-5-甲基四氢叶酸的合成及其研究

Study and Synthesis of ( 6S ) - 5-Methyltetrahydrofolic Acid

本文研究了接受高剂量氨甲喋呤（MTX）结合甲酰四氢叶酸钙（CF）保护化疗的20例恶性肿瘤病人的药代动力学特性。

High-dose of methotrexate ( MTX ) was administered with citrovorum factor ( CF ) to 20 patients with malignant tumor .

四氢叶酸（THF）辅酶是生物合成与细胞代谢的过程中一碳单元转移的载体。

Tetrahydrofolate ( THF ) cofactor is the carrier of one-carbon unit on biosynthesis and cell metabolize .

目的：探讨甲酰四氢叶酸钙（CF）调变5－氟脲嘧啶（5－FU）对不同胃癌原代细胞株的增殖抑制效应。

Background / Aims : To evaluate the regulatory effect of calcium folinate ( CF ) on 5-fluorouracil ( 5-FU ) against human gastric cancer cell .

目的观察以高剂量甲酰四氢叶酸钙（CF）与氟尿嘧啶（5-FU）为主的联合化疗方案治疗晚期肿瘤的疗效。

PURPOSE To observe the curative effects obtained from combined chemotherapy of late malignant tumors with high-dose CF and 5-FU used as amain drug .

PCR-RFLP法检测N~5，N~（10）-亚甲基四氢叶酸还原酶基因多态性及其临床意义

Detection of N ~ 5 , N ~ 10-methylenetetrahydrofolate reductase gene polymorphism by using PCR-RFLP and its clinical significance

简要介绍（6S）-5-甲基四氢叶酸的结构和应用。

The structure and application of ( 6S ) - 5-methyltetrahydrofolic acid were briefly introduced .

采用MTT比色法检测了甲酰四氢叶酸增强5－氟尿嘧啶对人食管癌Eca－109细胞的细胞毒效应。

Cytotoxic effects of 5-fluorouracil ( 5-Fu ) combined with leucovorin ( LV ) on human esophageal carcinoma Eca-109 cells were examined in vitro by using colorimetric MTT assay .

氨甲叶酸（简称MTX）为甲酰四氢叶酸的抗代谢物，长期以来一直用作治疗肿瘤的化疗药物。

Methotrexate ( MTX ) is an antimetabolite of folic acid which has been used for a long time in thechemotherapy of tumours .

方法33例晚期大肠癌患者，均以甲酰四氢叶酸钙（CF）与5氟脲嘧啶（5Fu）联合化疗加健脾和胃、益气养血中药治疗。

Methods 33 patients with advanced carcinoma of large intestine were treated by CF / 5 Fu combined with traditional Chinese medicine .

叶酸（FolicAcid）系由2-氨基-4-羟基-6-甲基蝶呤、对氨基苯甲酸及谷氨酸组成的水溶性B族维生素，在人体内转化成四氢叶酸，参与氨基酸及核酸的合成。

Folic acid is Vitamin Bc made up of 2-amino-4-hydroxyl-6-methylpterin , para-amino benzoic acid and glutamic acid , transforming into tetrahydro-folic acid in the human body , the ones that participated in formatting amino acid and nucleic acid .

四氢叶酸辅酶（THF）在生物体内的作用是转移不同氧化态的一碳单元，当一碳单元处于甲醛氧化态时，活性部分是具有五元环状结构的咪唑烷环。

When the one-carbon unit is at the formaldehyde oxidation level , the imidazolidine with a five-membered ring structure is the active site .

5-氟尿嘧啶及其与甲酰四氢叶酸合并用药对7402肝癌细胞株N-ras癌基因表达的影响

Effects of 5-fluorouracil and Its Combination with Folinic Acid on Expressions of N-ras Oncogene in 7402 Hepatocarcinoma Cell Line

目的比较四氢叶酸（LV）注射与口服给药解救大剂量甲氨蝶呤（HD-MTX）毒性的效果，了解口服解救安全性。

Objective To compare the rescue effect of leucovorin taking orally with that of via intramuscular in high-dose methotrexate ( HD-MTX ) chemotherapy .

目的：探讨上海社区人群亚甲基四氢叶酸还原酶（methylenetetrahydrofolatereductase，MTHFR）基因多态性与原发性高血压的关系。

Objective : To explore the relationship between methylenetetrahydrofolate reductase ( MTHFR ) polymorphism and risk of essential hypertension among Shanghai community based population .

目的探讨亚甲基四氢叶酸还原酶（methylenetetrahydrofolatereductase，MTHFR）基因多态性与血液透析（hemodialysis，HD）患者心、脑血管疾病的关系。

Objective To investigate the relationship between methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphism and cardiovascular and cerebrovascular diseases ( CVD ) in hemodialysis ( HD ) patients .

目的：探讨同型半胱氨酸（Hcy）代谢相关酶N5,10亚甲基四氢叶酸还原酶（MTHFR）及胱硫醚β合酶（CBS）基因突变对脑梗死的致病作用。

Aim : To study the effect of gene mutations of methylenetetrahydrofolate reductase ( MTHFR ) and cystathionine β - synthase ( CBS ) in cerebral infarction .

结论：应用HDMTX（3.0g/m2）持续24h静滴时，推迟四氢叶酸解救的开始时间和减少四氢叶酸总量不增加毒性作用的发生率和严重程度，且有利于提高疗效。

Conclusion : In HDMTX regimen , a reduced and delayed leucovorin rescue can improve the efficacy of HDMTX without increasing drug induced toxicity .

目的探讨北方乡村妇女亚甲基四氢叶酸还原酶（MTHFR）基因多态性与神经管畸形的关系。

Objective To explore relationship between methylenetetra hydrofolate reductase ( MTHFR ) polymorphism and neural tube defects ( NTDs ) of women in the northern countryside .

在人体内叶酸携带一碳单位形成5-甲基四氢叶酸（5-MethyltetrahydrofolicAcid）、亚甲基四氢叶酸等活性形式发挥作用，其中5-甲基四氢叶酸是人体内活性叶酸的主要存在形式。

In man , folic acid carries one carbon unit to form 5-methyltetrahydrofolic acids methylene tetrahydrofolic acid and other active forms , then they become useful . 5-Methyltetrahydrofolic acid is the major folate in man .

术后1周，给予5Fu500mg/M2，CF（甲酰四氢叶酸钙）30mg或300mg/M2，静注，每日1次，共5d，以后每月1次，共5～6次；

Fu 500 mg / m 2 , CF ( Leucovorin ) 30mg / m 2 or 300 mg / m 2 , iv qd for five times one week after operation ;

对照组16例，MTX多次静脉注射，次日加四氢叶酸钙解毒。

The control group ( 16 cases ) was treated by multi & dose Methotrexate ( MTX ) introvenous injection and the next day with Calcium Folinate ( CF ) for removing toxic material .

血浆同型半胱氨酸水平及其代谢酶N5，N10亚甲基四氢叶酸脱氢还原酶基因多态性与Binswanger病的关系

Association between the plasma homocysteine level , gene polymorphism of N5 , N10 methylene tetrahydrofolate reductase and Binswanger 's disease

目的观察羟基喜树碱（HCPT）、甲酰四氢叶酸钙（CF）、5-氟尿嘧啶（5-FU）联合治疗恶性消化道肿瘤的近期疗效及毒副反应。

Objective To observe the clinical efficacy and toxicity of the combination chemotherapy with hydroxycamptothecin ( HCPT ), leucovorin ( CF ) and 5-fluorouracil ( 5-FU ) in the treatment of malignant tumor of digestive tract .

目的探讨叶酸、维生素B12、N5，N10-亚甲基四氢叶酸还原酶（MTHFR）基因及血浆同型半胱氢酸（Hcy）水平与Alzheimer病（AD）的关系。

Objective : To study the relationship between plasma folate , vitamin B12 , plasma homocysteine ( Hcy ) levels and the polymorphisms of MTHFR gene in Alzheimer ′ s disease ( AD ) .

结论：①同型半胱氨酸代谢关键酶基因亚甲基四氢叶酸还原酶C677T存在多态性，无民族差异。

CONCLUSION : ① There is polymorphism in Hcy metabolic key enzyme gene MTHFR C677T , and no difference is found between ethnic groups .

目的探讨不同性别原发性高血压患者中血清叶酸水平与甘油三酯水平及亚甲基四氢叶酸还原酶（MTHFR）C677T多态性位点的相关性。

Objective To explore the association of the serum folic acid level with triglycerides level and C677T polymorphisms in methylenetetrahydrofolate reductase ( MTHFR ) in the primary hypertensive patients .

目的研究同型半胱氨酸代谢关键酶亚甲基四氢叶酸还原酶（methylenetetrahydrofolatereductase，MTHFR）基因C677T多态性与糖尿病合并冠心病发病的关系，探讨MTHFR是否为糖尿病合并冠心病的易感基因。

Objective To explore the significance of the gene polymorphisms of methylenetetrahydrofolate reductase ( MTHFR ) C677T in type 2 diabetes mellitus ( DM ) with coronary heart disease ( CHD ) .