利血平

目的：建立反相液相色谱法测定复方利血平片中维生素B6、氢氯噻嗪、硫酸双肼屈嗪、维生素B1、氯氮章和利血平的含量。

Objective : RP - HPLC method was developed to separate and determine six components in compound reserpine tablets .

HPLC测定复方利血平片中氢氯噻嗪的含量

Content determination of Hydrochlorothiazide in Compound Reserpine Tablets by HPLC

HPLC法测定复方降压素片中利血平含量

Determination of reserpine in compound hypotensive tablet by HPLC

利血平对马桑内酯致痫作用和癫痫小鼠脑内cAMP水平的影响

Effect of Reserpine on Both CL Seizures and cAMP Levels in Seizure Mice Brain

韭菜根液能减轻利血平诱发胃粘膜的损伤，提高SOD活性，降低MDA含量。

The chives roots juice reduce gastric mucosa injury and MDA content but increase SOD activity .

人参茎叶皂甙对正常和利血平化小鼠肝、肾组织的DNA，RNA及蛋白质合成的影响

Effects of saponin of GSL on DNA RNA and protein synthesis of liver and kidney in normal and reserpinized mice

韭菜根液对利血平诱发胃溃疡大鼠胃粘膜SOD、MDA的影响

Effects of Chives Roots Juice on SOD and MDA in Gastric Mucous Membrane of Rats with Stomach Ulcer Induced by Reserpine

除正常对照组外，各组小鼠均采用利血平复制脾虚证动物模型，腹腔注射利血平0.2mg/（kg·d）。

Except mice in normal control group , model mice of spleen deficiency syndrome were established by injecting 0.2 mg / ( kg · d ) reserpine intravenously .

结果：IL-12及IL-18引起明显脾虚证的表现，与利血平制作脾虚动物模型组相似。

Results : IL-12 and IL-18 induced prominent spleen deficiency syndrome similar with that induced by reserpine .

用利血平法建立北京鸭实验性脾虚模型，用半定量RT-PCR法检测了十二指肠、空肠CCK和VIP表达的变化。

The models of SDP were established by injecting Reserpine , expression of CCK , VIP was determined by semiquantitative RT-PCR .

联合利血平和MPTP制备小鼠帕金森病模型的实验研究

Experimental study on Parkinson disease model induced by reserpine plus MPTP in C57BL mice

采用利血平制作脾虚动物模型组，IL组每日腹腔注射IL-12、IL-18。

Spleen deficiency model was prepared with reserpine . Mice in IL group were injected with IL-12 and IL-18 intraperitoneally each day .

结论利血平所致大鼠AMH模型各生化指标稳定，但C组死亡率较高。

Conclusion The rat experimental model of AMH in groups B and C is more steady than group A , but mortality of group C is high .

将动物利血平化或icv心得安均明显减弱胃张力并取消抑制相；

Pretreat-ment with reserpine or icv injection of propranolol remarkably impaired the gastric tension and abolished the inhibition phase ;

根据以上结果，苯乙肼似能加强酪胺释放心脏NA的作用，能部分减少利血平对心脏，NA的耗尽作用，但可完全对抗胍乙啶的释放作用。

The above results may be summarized by saying that the NA-releasing action of tyramine seemed to be augmented , that of reserpine was partly diminished and that of guanethidine was wholly antagonized by phenelzine .

方法采用小鼠利血平拮抗实验和5-羟色胺酸（5-HTP）诱导的甩头实验。

Methods The reserpine reversal test and 5-HTP induced head-twitches test were used in mice .

利血平皮下注射的方法制作脾虚动物模型，用电子天平测脾重，放射免疫法测定IL-2、IL-6及TNF-α等，并与正常对照组、中药治疗组比较。

Reserpine subcutaneous injection method of producing animal models of spleen , spleen weight measured by electronic balance , measured by radioimmunoassay IL-2 , IL-6 and TNF-a and so on . Results : 1 .

从实验结果可以看出，HRV的中枢作用以对延脑及视丘下部血管运动中枢的抑制较为显著，周围作用则为一定程度的抗交感作用，与单纯的利血平有所不同。

It appeared therefore that centrally HRV inhibited remarkably the vasomotor centers of the medulla and hypothalamus , and peripherally it seemed to be sympatholytic to a certain extent .

结果：单独加入VMAT抑制剂利血平对PC12细胞无毒性作用；

Results ; Reserpine , an inhibitor of VMAT , itself had no poisonous effect on PC12 cells .

⑵通过利血平建立药物诱发的抑郁小鼠模型，观察SRP对利血平诱发小鼠体温下降、眼睑下垂和活动抑制的影响。

⑵ In this study , we set up the drug-induced depression model by reserpine , and then observed the ptosis , akinesia and hypothermia which induced by reserpine .

结果BCPT可拮抗利血平诱导的小鼠上眼睑下垂及运动不能，并增加5-HTP诱导的小鼠甩头次数。

Results BCPT could reverse the blepharoptosis and the akinesia induced by reserpine and increase the number of head-twitches induced by 5-HTP in mice .

在体研究表明，dl-THP在较大剂量下与利血平相似，降低犬鼠体温。

In vivo , dl-THP , like reserpine , at relatively large dose lowered the body temperature of rats .

除对照组给予等体积的生理盐水外，其余组每日灌胃300mg/kg甲状腺素混悬液及2mg/kg利血平，连续7d进行甲亢阴虚型小鼠造模。

In addition to the control group , the other groups were given 300mg / kg thyroid and 2mg / kg reserpine saline suspension for 7 days to establish the mouse model of hyperthyroidism Yin-deficiency .

方法应用琼脂稀释法检测表皮葡萄球菌耐药株和敏感株在加入主动外排抑制剂利血平和碳酰氰间氯苯腙（CCCP）后，对环丙沙星、司帕沙星的最低抑菌浓度（MIC）变化情况。

Methods The influence of carbonyl cyanide m-chlorophenylhydrazone ( CCCP ) or reserpine in Staphylococcus epidermidis on ciprofloxacin and sparfloxacin minimal inhibitory concentration ( MIC ) were detected by using agar dilution method .

51只大鼠、15只家犬和4只家猫于实验前24hip优降宁30～50mg/kgbid，实验时先将动物麻醉，再iv利血平2mg/kg，观察血压变化。

Thirty-fifty mg / kg of pargyline bid was given ip to 51 rats , 15 dogs and 4 cats on the day before experiments . The animals - were anesthetized during experiments and the changes of blood pressure to reserpine 2 mg / kg iv were observed .

五灵脂（简称WLZ）经加工后萃取出4个部分：WLZ－A、B、C、D，用Shay模型和利血平模型研究五灵脂保护胃粘膜作用的有效成分及其作用机制。

Four components from faeces trogopterori ( WLZ ) extract : WLZ A , B , C , D were isolated for elucidating the protective effect of which on gastric mucosa and identifying the effective principle . Shay model and reserpine model were used .

用利血平制备脾虚模型，检测补中益气汤对脾虚小鼠NK及TNF活性的影响，结果表明：脾虚小鼠NK活性明显低于正常，TNF毒性远高于正常。

By using the model of spleen-asthenia made with Reserpine , the activities of NK and TNF in spleen-asthenia mice were studied . Th results showed that the activity of NK was below the normal level obviously while toxicity of TNF was far above its normal level in spleen-asthenia mice .

结论TAEP具有与利血平相似的单胺排空作用，是TAEP对中枢神经系统镇静安定的作用机制。

Conclusion TAEP has an evacuating action of monoamine similar to Reserpine . This may be considered as one of the mechanisms of sedative and tranquilizing effect CNS .

四逆散有效部位大、小剂量（600、300mg/kg）可以拮抗利血平降低小鼠体温、引起小鼠眼睑下垂的作用，明显增加5-HTP诱导小鼠的甩头次数。

The high and low doses of the effective fraction of Sini Powder ( 600mg / kg , 300mg / kg ) antagonized the descent of body temperature and ptosis induced by reserpine , and increased significantly the frequency of mouse head flick induced by 5-HTP .

结果胃乐散三个剂量组（分别为0.4g/kg、0.2g/kg、0.1g/kg）灌胃对大鼠幽门结扎和乙酸引起的胃溃疡均有明显保护作用；对利血平诱发小鼠急性胃溃疡则无明显作用；

Results Wei Le San ( 0.1 ? 0.2 ? 0.4g / kg ) had protection against the ulcers in the pylorus ligation induce and acetic acid induce models in rat , but no effect in the reserpine induce model in mice .