内源性抗原

小鼠内源性抗原提呈树突状细胞疫苗的抗瘤作用

Antitumor effects of endogenous antigen presenting dendritic cells in mice

特别是可以模拟内源性抗原的加工呈递过程，诱发特异性细胞免疫反应。其免疫途径有肌肉注射、皮下注射、静脉注射等。

It also can mimic the processing and presenting of endogenous antigen , thus inducing T cell response .

抗原处理相关转运体蛋白（Transporterassociatedwithantigenprocessing，TAP）在内源性抗原提呈过程中有重要作用，负责内源性抗原从胞浆到内质网（ER）腔的转运。

The transporter associated with antigen processing ( TAP ) plays a pivotal role in the presentation of intracellular antigen by translocating intracellular antigenic peptides from the cytosol into the lumen of endoplasmic reticulum ( ER ) .

其抗瘤机制是诱导内源性抗原特异性CTL反应，由典型的MHC-I限制的CD8+T细胞所介导的。

The mechanism of which might be that it can induce internal antigen-specific CTL response modulated by the typical MHC-class I restricted CD8 ~ + T cells .

本文建立了蛋白酶体裂解内源性抗原蛋白的QSAR模型来研究蛋白酶体对抗原蛋白裂解的特异性，并采用PLS方法求解模型。

The QSAR model of proteasomal cleaving antigen protein is built in order to study the specificity of the proteasome cleaving antigen protein , and PLS method is used to solve the model .

IL-12可作为治疗药物以内源性抗原的佐剂形式促进肿瘤或病毒特异性免疫，抑制肿瘤生长或治疗病毒感染；

IL-12 can be used as a therapeutic agent , an endogenous adjuvant , to promote the specific immunity of tumor or virus , and to inhibit tumor growth or to treat virus infections .

HLA-Ⅰ在APM成员的协助下，完成内源性抗原肽的组装、负载和提呈，介导抗肿瘤或病毒的细胞和体液免疫。

HLA - ⅰ works together with the members of APM in the assembling , loading and presentation of endogenous antigenic peptide , mediates anti-tumor or anti-viral cellular and humoral immunity .

在内源性抗原的加工提呈途径中，真核细胞中的泛素&蛋白酶体系统对内源性抗原蛋白发挥着重要的降解功能。

The ubiquitin-proteasome system of the eukaryote plays an importance role in the process of endogenous antigen degradation .