免疫逃逸

FasL基因表达与食管癌免疫逃逸关系的研究

Tumor immune escape and FasL gene in esophageal carcinoma

大肠癌细胞功能性Fas配体的表达度与肿瘤免疫逃逸的关系

Relationship between expression of functional Fas ligand in human colon cancer cells and tumor 's immune escape

重组HBsAg免疫逃逸突变体的表达及其抗原性分析

Expression of recombinant antibody-escape-mutants of HBsAg and its antigenic analysis

Fas系统与肿瘤免疫逃逸的研究进展

Fas system and tumor immune evasion : An update

Fas配体在膀胱肿瘤细胞系免疫逃逸中的作用

Role of Fas ligand in immune evasion in bladder neoplasms cell line in vitro

针对DC抗肿瘤机制、妇科肿瘤的免疫逃逸及在妇科肿瘤上的应用进行了研究。

This article makes a research on DC anti-tumor mechanism , the gynecology department tumor immunity escapes and the gynecology department tumor application and the progress .

目的探讨Fas系统在肝细胞癌免疫逃逸及免疫反击中的作用。

Objective To probe the potential role of Fas system in immune escape and counterattack involved in HCC .

膀胱移行细胞癌组织Fas/Fasl和c-myc表达与肿瘤免疫逃逸相关性研究

Relationship between expressions of Fas / Fasl and c-myc in BTCC and immune evasion of tumor

ICAM-1表达减少可能是肝癌发生过程中免疫逃逸的重要机制；

The decrease of ICAM-1 expression might be related to development of HCC by immune escape mechanism .

张林琦说，HIV具有免疫逃逸机制，更微妙的是，HIV恰恰感染的是免疫系统中对抗感染的免疫细胞。

Said Zhang Linqi , HIV immune escape mechanism is more subtle , HIV infection is precisely the immune system fight the infection of immune cells .

IL-18也可促进肿瘤发展和免疫逃逸，诱导血管发生和转移。

IL-18 has also been associated with cancer progression and immune escape , is able to induce angiogenesis , metastasis .

结论肿瘤患者NK细胞表面NKG2A/NKG2D表达失衡，可能是肿瘤免疫逃逸的机制之一。

Conclusions Imbalance expression of NKG2A and NKG2D on peripheral NK cell of patient with tumor may be an important factor in tumor immunological escape .

目的探讨HLA-G在肿瘤免疫逃逸中的作用。

【 Objective 】 To explore the effect of HLA - G in immune escape .

肿瘤分泌的可溶性PD-L1能同时在局部和全身水平反映肿瘤的免疫逃逸功能。

Soluble PD-L1 reflects the scale of tumor immune escape both locally and systemically .

背景与目的：由于丙型肝炎病毒快速产生耐药性和免疫逃逸，预防和治疗丙型肝炎病毒（HCV）感染面临着挑战。

BACKGROUND & AIMS : Hepatitis C virus ( HCV ) infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape .

CD4~+CD25~+调节性T细胞和TLRs在幽门螺杆菌免疫逃逸中的作用

Role of CD4 ~ + CD25 ~ + regulatory T cells and TLRs in immune escape of Helicobacter pylori

目的：探讨肿瘤细胞分泌的可溶性细胞因子营造的微环境对树突细胞（DCs，Dendriticcells）的分化发育的影响，以进一步揭示肿瘤的免疫逃逸机制。

Objective : To study the influence of microenvironment created by dissoluble cytokines derived from tumor cells on the differentiations of dendritic cells ( DC ), and to investigate the mechanism by which tumors escape from immune recognition .

目的：探讨膀胱癌可溶型Fas配体（sFasL）在免疫逃逸机制中的作用。

Objective : To investigate the role of soluble Fas ligand ( sFasL ) in bladder neo-plasm in the mechanism of immune evasion .

前期研究发现，HLA-G分子在胃癌、肺癌等肿瘤细胞中也有高表达，并对肿瘤细胞的免疫逃逸具有重要作用。

Preliminary study found that HLA-G was up-expressed in gastric carcinoma and lung cancer cells and contributed to tumor immune escape .

但肿瘤细胞也可通过表达TRAIL，产生免疫逃逸或免疫赦免，且TRAIL的作用还受到NFκB或靶细胞表达TRAIL受体类型和数量的影响。

But a tumor emerges immune escape or immune privilege by expressing TRAIL on itself . The action of TRAIL is influenced by NF - κ B or type and amount of TRAIL receptors on target cell .

Fas配体（FasL）是肿瘤坏死因子受体/神经生长因子家族成员，可激活在细胞凋亡中起关键作用的caspase3，并可导致肿瘤细胞的免疫逃逸。

Fas ligand ( FasL ) is one of tumor necrosis factor / nerve growth factor family activating caspase-3 , a key proteinase in cell apoptosis and leading immune escape in tumor cells .

TLR4参与肿瘤免疫逃逸除了外源性活化机制外，肿瘤微环境中的内源性配体同样可能发挥重要作用。

Besides , the exogenous activation and endogenous ligands in tumor microenvironment may also play important roles in tumor immune escape triggered by TLR4 .

结论：白血病细胞表达的IDO活性能阻抑外周T淋巴细胞的增殖，它可能参与了肿瘤免疫逃逸。

It is concluded that IDO activity expressing in leukemia cells can suppress T-lymphocyte proliferation responses , which may be contributing to tumor immune escape .

检测Fas、FasL在上皮性卵巢癌及其肿瘤浸润淋巴细胞（TIL）中的表达，探讨Fas系统在卵巢癌免疫逃逸中的作用。

Objective : To detect the expressions of Fas , FasL in human epithelial cancer ( OEC ) tissues and their tumor infiltrating lymphocytes ( TIL ) and explore the mechanism of neoplasmas escaping from immune surveillance .

Fas/FasL系统介导的细胞凋亡机制、Bcl-2介导的抑细胞凋亡机制和FasL介导的细胞免疫逃逸机制相互作用，互为因果，对增殖-凋亡平衡和细胞分化发挥重要的调控作用。

Interaction among Fas-FasL system mediated apoptosis mechanism , Bcl-2 mediated apoptosis inhibition mechanism and FasL mediated cell immune escape mechanism , plays an important role in regulating control on the balance between proliferation and apoptosis as well as cellular differentiation .

结论：TSF下调口腔鳞癌细胞HLA-A和CD86的转录和表达，造成肿瘤的免疫逃逸，有助于肿瘤的转移和演进。

Conclusion : TSF down-regulates the expression of HLA-A and CD86 in oral squamous cells , and therefore the escape from immune may result in tumor progression and metastasis in vivo .

sPD-L1评估肿瘤免疫逃逸潜能的作用类似于其他血清肿瘤标志物在评价肿瘤负荷中的水平。

SPD-L1 possessed the efficiency in evaluating the potential of immune escape similar to that in evaluating tumor burden for other tumor markers .

多数肿瘤细胞高表达FasL，可以与Fas阳性的活化T淋巴细胞结合，引起T淋巴细胞的凋亡，这可能是肿瘤免疫逃逸的机制之一。

A majority of tumor cells represent FasL in a higher level , which may connect with Fas positive and activated T cells and induce the apoptosis of T cells , and it may be ascribed to one of the mechanisms of tumor immune escape .

结论：sFasL在膀胱癌的免疫逃逸机制中发挥重要作用，与膀胱癌发生、发展密切相关。

Conclusion : sFasL plays important role in the mechanism of immune evasion in bladder neo-plasm , and it has close relationship with the onset and development of bladder neoplasm .

双歧杆菌是人和动物肠道内重要的生理菌，其表面分子脂磷壁酸（lipoteichoicacid，LTA）已被证实具有抗肿瘤作用，但其在逆转肿瘤免疫逃逸中的作用尚未见报道。

Bifidobacteria is one of important intestinal physiological bacterium of human and animals , and its surface molecule lipoteichoic acid ( LTA ) has been proven to have anti-tumor effects , but the role of LTA in reversal tumor immune escape has not been reported .