伏立康唑

分离物在体外对伏立康唑、两性霉素B和米卡芬净敏感。

The isolate was susceptible to voriconazole , amphotericin B , and micafungin in vitro .

用HPLC法测定伏立康唑中有关物质和降解产物，与主药有很好的分离效果。

An RP-HPLC method for the determination of related substances and decomposition products in voriconazole was established .

目的比较伏立康唑、氟康唑和两性霉素B在体内对克柔念珠菌的抗真菌活性。

Objective To compare the antifungal activities of voriconazole against Candida krusei with fluconazole and amphotericin B in vivo .

米卡芬净与伏立康唑或两性霉素B联合最有效，并且是唯一能够延长存活期并减少肾脏和脑部真菌负荷的治疗策略。

Micafungin combined with voriconazole or amphotericin B was the most effective , these being the only treatments able to prolong survival and to reduce the fungal load in the kidneys and brain .

本研究评价了米卡芬净、两性霉素B和伏立康唑单独用药，二联用药和三联用药治疗播散性多育赛多孢感染鼠类模型的疗效。

We have evaluated the efficacies of micafungin , amphotericin B , and voriconazole , alone and in double and triple combinations , in a murine model of systemic infection by Scedosporium prolificans .

伏立康唑是预防IFI的一线抗真菌制剂。

Voriconazole is the first-line antifungal agent for prevention of IFI .

各真菌对5-氟胞嘧啶、两性霉素B、伏立康唑敏感性较高，分别为99.81%、100%、99.17%；对氟康唑、伊曲康唑敏感性较低，分别为94.87%，93.92%。

The sensitivities of the fungi to 5-fluorocytosine 、 amphotericin B 、 voriconazole were high , respectively 99.81 % , 100 % , 99.17 % ; and to fluconazole 、 itraconazole were low , respectively 94.87 % , 93.92 % .

伏立康唑被推荐用于大多数侵袭性曲菌病患者的首要治疗措施（A-I）。

Voriconazole is recommended for the primary treatment of invasive aspergillosis in most patients ( A-I ) .

5个处理组中，伏立康唑10mg组的组织载菌量与死亡率（0%）均最低；

Among all the five groups , the tissue burden and the cumulative mortality ( 0 % ) of voriconazole 10 mg group were the lowest .

伏立康唑（voriconazole）是第2代三唑类抗真菌药，具有抗菌谱广、抗菌效力强的特点，尤其对于侵袭性曲霉菌侵润所致感染疗效好。

Voriconazole is a second-generation azole antifungal agent that shows the characters of broad-spectrum and strong antibacterial , especially has good efficacy to the infection induced by invasive aspergillus .

究其原因，是因为伏立康唑对细胞色素P450-3A4活性有强大的抑制作用。

The present drug2013drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole .

结果对受试菌株总体而言，伏立康唑的活性最高（MIC90≤0.5μg/ml）。

Results Overall , voriconazole was the most active against all the tested clinical Candida isolates ( MIC_ ~ 90 ≤ 0.5 μ g / ml ) . The MIC_ ~ 90 of voriconazole against the 6 Candida were ranked from the lowest to the highest as C. albicans , C.

伏立康唑对眼部常见分离真菌的体外药敏实验研究

In vitro susceptibility test of voriconazole against ocular fungal isolates

伏立康唑治疗肾移植术后肺部真菌感染

Effect of Voriconazole on Pulmonary Fungals Infection after Renal Transplantation

给她用伏立康唑滴液，希望是曲霉菌吧。

Get her on a voriconazole drip and hope she has aspergillus .

伏立康唑体外真菌药敏试验两种方法对比研究

Comparison of two methods of antifungal susceptibility test of voriconazole

伏立康唑成功治疗镰刀菌性眼内炎及联合卡泊芬净成功治疗曲菌性眼内炎

Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin

伏立康唑治疗儿童血液病合并侵袭性真菌感染的疗效观察

Effect of Voriconazole in the treatment of childhood hematologic disease with invasive fungal infection

中国5所医院念珠菌属对氟康唑和伏立康唑的耐药性监测

Surveillance of resistance to fluconazole and voriconazole in Candida isolates from 5 hospitals in China

三唑类抗真菌药物伏立康唑的合成

Synthesis of a triazole antifungal drug voriconazole

伏立康唑与氟康唑在恶性血液病真菌感染治疗中的临床观察

Clinical observation of voriconazole and fluconazole in the treatment for malignant hemopathic patients with invasive fungal infection

伏立康唑与其他5种抗真菌药体外抗念珠菌活性的比较研究

Comparison of the Activities of Voriconazole with Other five Antifungal Agents Against Candida spp . in Vitro

使用像伏立康唑那样病人可以耐受的广谱抗真菌药会引起关于抗真菌治疗治疗时间窗的争论。

The availability of tolerable broad-spectrum antifungals like voriconazole stimulated the discussion about optimal timing of antifungal therapy .

目的：建立测定人血浆中伏立康唑浓度的液相色谱-串联质谱联用法。

Objective : To develop a sensitive and specific LC-MS-MS method for determination of voriconazole in human plasma .

很少资料可以用来指导治疗对伏立康唑不起反应的曲菌病。

In patients whose aspergillosis is refractory to voriconazole , a paucity of data exist to guide management .

本病例报告了一例肾移植患者伏立康唑与他克莫司之间的相互作用。

This report presents a case of drug2013drug interaction between voriconazole and tacrolimus in a kidney transplant recipient .

伏立康唑拆分方法的改进

Improved resolution of voriconazole

伏立康唑治疗缺血性脑卒中患者耐氟康唑白色念珠菌肺部感染

The effect of voriconazole for the treatment of fluconazole resistant Candida albicans pulmonary infection in patients with cerebral infarction

两个新的三唑类当中，国际指南推荐伏立康唑作为急性侵袭性曲霉病的初始治疗。

Of the two newer triazoles , voriconazole has been recommended in international guidelines as primary therapy for acute invasive aspergillosis .

“泊沙康唑对于非伏立康唑治疗适宜患者可能是一个有用的补救治疗手段，”研究人员总结道。

" Posaconazole may be a useful salvage option for patients who are not candidates for voriconazole treatment ," the authors conclude .