临床合理用药

完善基本药物制度，促进临床合理用药

Improving National Essential Drug System and Promoting Clinical Rational Drug Use

前言：目的：综述盐酸氟西汀的各种不良反应，为临床合理用药提供资料。

Objective : To review various adverse reactions of fluoxetine hydrochloride in order to provide the data for clinical rational drug use .

目的利用PASS监控我院医嘱用药，以提高临床合理用药水平。

Objective To monitor medical orders by using PASS so as to improve rational use rate of drug .

目的：建立人血浆中福辛普利拉HPLC测定法，为血药浓度监测和临床合理用药提供方法学基础。

Objective : To establish a HPLC assay method for the determination of fosinoprilat in human plasma .

目的分析利巴韦林治疗SARS患者与心率减慢的关系，为临床合理用药提供参考。

Objective : To investigate whether bradycardia is related with ribavirin treatment in SARS patients .

结论PASS有助于提高临床合理用药水平，但该系统存在的不足有待不断完善。

CONCLUSION : PASS system is conducive to rational drug use in clinics , yet it is still for from being perfect thus further improvement is needed .

结论CRP的测定有助于儿童肺炎早期的鉴别诊断，指导临床合理用药。

Conclusion The detection of CRP can help early diagnosis of childhood pneumonia to guide rational drug use in clinical .

结论：医疗工作者应协同做好ADR监测工作，促进临床合理用药。

CONCLUSION : Medical worker should work cooperatively in the monitoring of ADR and promote rational drug use in the clinic .

结论医院相关专业技术人员应重视ADR监测工作，促进临床合理用药。

Conclusion The technologist in hospital should attach the stress to monitoring ADR for facilitating the rational use of clinical drug .

目的了解医院产超广谱β内酰胺酶（ESBLs）大肠埃希菌（E.coli）和肺炎克雷伯菌（K.pm）流行及耐药情况，以指导临床合理用药。

Objective To determine the prevalence of strains producing extended-spectrum β - lactamases ( ESBLs ) among E. coli and K.

研究中药雷公藤多苷治疗类风湿关节炎（RA）的起效用药量，以指导临床合理用药。

Objective To investigate the effective dosage of polyglucoside of tripterygium Wilfordii in treating rheumatic arthritis ( RA ) for guiding the clinical rational administration .

目的：研究解脲支原体（UU）对10种抗生素耐药情况，指导临床合理用药。

Objective : In order to study the status of drug resistance of ureaplasma urealyticum ( UU ) and instruct reasonable application antibiotics in clinic .

目的分析女性生殖道感染者解脲支原体（UU）和人型支原体（MH）检出情况及体外耐药性，以指导临床合理用药。

Objective : To analyse drug resistance and detection of ureaplasma urealyticum ( UU ) and mycoplasma hominis ( MH ) among women with genital infection .

目的：了解普通外科监护病房（ICU）医院获得性感染常见细菌及药敏结果，以指导临床合理用药。

Objective : To study the pathogenic bacteria and their drug sensitivity in general surgical intensive care unit ( SICU ) so as to guide reasonable clinical medicine application .

目的探讨线粒体途径在肿瘤坏死因子凋亡诱导配体（TRAIL）诱导结肠癌细胞凋亡过程中的调节作用，为临床合理用药提供理论指导。

Objective To explore the effects of mitochondrial pathways on apoptosis in colon carcinoma cells induced by Tumor necrosis factor related apoptosis inducing ligand and offer evidences for TRAIL application in clinic .

目的了解天津滨海地区解脲脲原体（Uu）和人型支原体（Mh）的耐药状况，指导临床合理用药。

Objective To study the resistance of Ureaplasma urealyticum ( Uu ) and Mycoplasma hominis ( Mh ) in Tianjin seaport and reasonable administration of therapeutic drug .

结论加强对ESBLs菌株及其耐药率监测，能指导临床合理用药，是预防和控制ESBLs细菌感染的重要措施。

Conclusion Strengthening the monitoring of bacterial drug resistance , is the important measure to guide clinical use of antibiotics and control ESBLS - producing bacteria infection .

结论：UU存在多重耐药，对UU进行药敏监测对指导临床合理用药及防止耐药株的发生有重要意义。

CONCLUSION : UU shows multiple drug resistance . The determination of the susceptibility of UU to antimicrobial agents can instruct reasonable medication and prevent the occurrence of drug resistance .

【目的】评价培养法检测肺炎支原体（MP）的性能，了解肺炎支原体的耐药状况，指导临床合理用药。

【 Objective 】 To estimate the capability of culture detection of mycoplasma pneumoniae and acquire the information about the present resistance characteristics in MP , and to instruct reasonable application of antibiotics clinically .

目的：监测我院下呼吸道产超广谱β-内酰胺酶（ESBLs）菌株耐药状况，指导临床合理用药。

Objective : To analysis the status of drug resistance of strains of extend spectrum β - lactamase ( ESBLs ) which isolated from the inpatients with lower respiratory tract infection .

目的分析重症监护病房（ICU）医院感染的病原菌分布及其耐药现状，为临床合理用药和控制医院感染提供依据。

OBJECTIVE To analyze the status quo of pathogenic bacteria distribution and drug resistance of hospital infection in intensive care unit , to provide evidence for the guidance of clinical rational administration and to decrease the hospital infection .

目的：调查主要肠杆菌科细菌和非发酵菌产AmpC酶和ESBLs的状况及对常用抗菌药物的耐药性，指导临床合理用药。

AIM : To study the drug resistance to extended spectrum β Lactamase ( ESBLs ) and AmpC β Lactamase ( AmpC ) produced from both the main enterobacteriaceae bacteria and non ferment bacteria .

结论核素测定GFR能较早发现患者肾功能的损害，对于临床合理用药、观察和保护肾功能有一定的价值。

Conclusion Determination of GFR by nuclide can detect early renal function damage . It is a certain useful value in clinical rational administration , clinical observation , protection of kidney function .

目的：研究阿米卡星（AMK）在老年呼吸系统感染患者体内的药动学，为临床合理用药提供依据。

OBJECTIVE : The pharmaceutics of Amikacin ( AMK ) in old patients with respiratory system infections was studied to provide a basis for clinical use .

广东人群使用CYP2C9底物药时，应进行相应的CYP2C9基因型检测，以指导临床合理用药和个体化医疗。

Genotyping of CYP2C9 will be helpful in guiding rational and individualized medication for individuals from Guangdong population which use drugs metabolized by CYP2C9 .

结论：加强ICU细菌耐药监测，了解细菌分布及耐药变化，指导临床合理用药，防止耐药菌株的传播。

CONCLUSION : Monitoring of drug resistance to bacterium in ICU should be strengthened , bacterial distribution and the changes of drug resistance should be investigated in order to direct rational drug usage in the clinic and prevent bacterial strains of drug resistance from being transmitted .

目的：了解女性生殖道解脲支原体（Uu）和人型支原体（Mh）的感染及药物敏感情况，为临床合理用药提供实验依据。

Aim : To study the inflammation of ureaplasma urealyticum ( Uu ) and mycoplasma hominids ( Mh ) in the female genital duct and to analyze the drug sensitivities of the mycoplasma , so as to provide data for clinical reasonable use of medicine .

目前，CYP2D6的生物学特征已被基本确定，这将十分有助于对CYP2D6的深入研究，从而为临床合理用药提供科学依据。

So far , the biological features of CYP2D6 have been basically defined , which will be helpful to the further study on CYP2D6 and therefore to the rational drug usage .

目的：研究头孢唑肟（Ceftizoxime，CZX）在5%葡萄糖输液中与维生素B6等6种注射剂配伍的稳定性，为临床合理用药提供科学依据。

OBJECTIVE : To study the stability of ceftizoxime ( CZX ) mixed with vitamin B 6 etc. in 5 % glucose injection solution , and provide a scientific basis for rationalized use of CZX .

为研究解脲尿枝原体（UU）的耐药情况，指导临床合理用药，采用UU培养和药敏试验盒测定10种抗生素对36例UU的体外抗菌作用。

Objective : To study the status of drug resistance of Ureaplasma urealyticum ( UU ) and instruct justifiable application of antibiotics clinically . Methods : Antibacterial activities of 10 antimicrobial agents against 36 cases of UU were determined using specific agent kit for UU culture and drug susceptibility test .