pnh

Establishment and identification of B cell lines with PNH phenotype

具有阵发性睡眠性血红蛋白尿症表型的B淋巴细胞株的建立

Treatment of PNH by chemotherapy and Chinese Medicinal Herbs

中西医结合使用化疗及中药治疗阵发性睡眠性血红蛋白尿症

Advances of Research in Evolution of PNH Clone

关于PNH克隆演变的研究进展

Soliris acts to block the complement system activity , including the destruction of PNH red blood cells .

它的机制主要通过抑制血液中补体系统的活性，从而使发育异常的红细胞免遭破坏。

Conclusion DA / HA regimen chemotherapy was safe and effective for refractory and relapsed PNH patients .

结论DA或HA方案是治疗难治、复发性PNH较为安全、有效的方法。

PNH , which usually develops in adults , is a disease characterized by red blood cells that develop abnormally .

PNH通常发生于成年人，是一种红细胞发生异常的疾病。

Objective To establish B cell lines from Patients with paroxysmal nocturnal haemoglobinuria ( PNH ) and normal controls .

目的建立阵发性睡眠性血红蛋白尿症（PNH）和正常人的B细胞株，用以研究PNH。

Conclusion : Prethrombotic state is present in PNH patients , which may be caused by hypercoagulability and low fibrinolytic activity .

结论：PNH患者存在血栓前状态，其发生可能主要与凝血机制亢进和纤溶机能减弱有关。

Objective To study the characteristic of clinical and laboratory examination of neonate paroxysmal nocturnal hemoglobinuria ( PNH ) .

目的探讨新生儿阵发性睡眠性血红蛋白尿（PNH）的临床及实验室检查特点。

During remission , PNH deficient red blood cells were mainly destroyed and the peripheral blood was negative for Ham 's test .

5例PNH缓解期酸溶血试验等无明显改变，患者外周血CD55和CD59缺陷红细胞的数量较少。

Ten patients with atypical manifestations were confirmed to be PNH , whereas 7 suspected cases were excluded by this measurement .

10例表现不典型或Ham试验阴性者经本法确诊为PNH，7例疑为本病者经本法否定。

Protection of PNH Red Blood Cells from Lysis by Transfering GPI anchored Protein Vesicles of Normal Human RBCs in vitro

体外转运富含GPI-蛋白的红细胞囊泡改善PNH溶血的探索

" There is a risk of anticoagulation in PNH , particularly when patients have low platelet counts ," he cautioned .

“PNH应用抗凝剂是有风险的，尤其是当血小板记数偏低的时候。”他警告说。

The consistency of the result of Ham test , Sucrose test , and Rous test are more reliable in the diagnosis of PNH .

Ham试验、糖水试验和Rous结果一致更有利于PNH的诊断。

Objective To learn more about the clinical and laboratory features of childhood paroxysmal nocturnal hemoglobinuria ( PNH ) and to improve the diagnosis .

目的研究儿童阵发性夜间血红蛋白尿（PNH）的临床和实验室检查特点，以提高诊断率。

Conclusion : T-lymphocytes from newly diagnosed PNH patients exerts an inhibitory effect on the in vitro growth of CFU-GM and BFU-E.

结论：初发PNH患者的T淋巴细胞对造血祖细胞的支持作用减弱，治愈的PNH患者的T淋巴细胞对造血祖细胞的支持作用恢复正常。

Conclusion The patients ' own serum , serum of AB type or of the patient 's the same type can be used in the screening test for PNH patients .

结论在PNH患者筛选中，Ham试验可以用自身血清替代AB血清或与患者同型的他人血清，而不用混合血清；

Depending on the severity of the disease , patients with PNH may have pain , fatigue and debilitating weakness and require frequent blood transfusions .

随着PNH的加重患者会出现疼痛、疲倦和虚弱的症状，并需要经常输血。

Objective : To unfold the proliferation and survival behavior of normal and abnormal early hematopoietic cells in paroxysmal nocturnal hemoglobinuria ( PNH ) .

目的：探讨阵发性睡眠性血红蛋白尿症（PNH）患者正常及异常造血细胞的增殖及生存特性。

In PNH Patients with severe hemolysis , the levels of serum α 2M were markedly de - , creased as compared with normal controls .

结果显示，轻度溶血的PNH患者血清α2M与正常对照比较差异无显著性；

Results The clinical situation of neonate PNH included jaundice in neonatal period , pallor anemia . But the typical soy urine was hard to detect .

结果新生儿PNH临床表现为新生儿期黄疸持续不退、面色苍白、进行性贫血，典型的酱油色样尿不易发现。

Methods : Flow cytometric technique along with antibodies against CD 59 was used to estimate the amount of GPI P deficient cells , characteristic of PNH abnormalities .

方法：用荧光标记的抗CD59抗体，以流式细胞仪检测缺失CD59的异常细胞。

Conclusion : There is important clinical significance for diagnosis of PNH patients in the determination of CD55 and CD59 expression on the red blood cells , granulocytes and lymphocytes .

结论：流式细胞仪检测PNH患者外周血红细胞、粒细胞、淋巴细胞CD55、CD59表面抗原具有重要的临床诊断意义。

The purpose of the study is to establish a colorimetric method of HEC toxin hemolysis test for diagnosis of paroxysmal nocturnal hemoglobinuria ( PNH ) .

本研究建立嗜水气单胞菌（HEC）毒素溶血试验比色法诊断阵发性睡眠性血红蛋白尿症（PNH）。

However , lymphocytes with PNH defect were found in only 14 patients . Conclusion : GPI anchored protein assay provided sensitive and specific method for the diagnosis of PNH .

结论：检测血细胞膜表面GPI锚蛋白分子表达可为确定或排除PNH的诊断提供敏感、特异的证据。

GPI-Pr Deficiency and Apoptosis of PNH Granulocytes

GPI-Pr缺失与阵发性睡眠性血红蛋白尿症粒细胞凋亡的关系

Each of 3 PNH patients had more than two point mutations of PIG-A gene . Insert or deletion mutation of PIG-A gene were not found .

其中有3例PNH患者同时存在2个以上的点突变，未发现插入或者缺失突变形式。

Results PNH could be diagnosed based on the results of FCM and routine tests for peripheral erythrocytes and granulocytes , which showed the characteristic defects when the HA broke out .

结果：5例PNH发作期患者酸溶血试验呈阳性，CD55和CD59缺陷红细胞在流式细胞术检测中具有特征性的改变；

Conclusion CD55 、 CD59 and CD34 antigens may act as the most sensitive marker of early diagnosis in PNH syndrome , and have a close correlation with prognosis .

结论CD55、CD59、CD34抗原表达率可做PNH早期诊断最敏感指标，并与预后转归密切相关。

The evolution of paroxysmal nocturnal hemoglobinuria ( PNH ) clone has been found very important in the pathogenesis of paroxysmal nocturnal haemoglobinuria .

随着阵发性睡眠性血红蛋白尿（PNH）发病机制研究的深入，很多学者都发现PNH细胞克隆的演变与疾病进展密切相关，可能是PNH发病的关键环节。