mnu

The analysis of the adducts is carried out after hydrolysis of MNU - DNA adduct .

加合物在水解后分析。

MNU time-dependently up-regulated the expression of c-jun and c-fos genes .

MNU可时间依赖性地上调即早基因的表达。

In central retinas of MNU-treated rats , the responses were progressively decreased following injection of MNU .

在经MNU处理的大鼠视网膜的中央位置，反应随着MNU注射逐渐减弱。

MNU did not affect morphology of other retinal neurons including bipolar cells , amacrine cells , horizontal cells and ganglion cells .

MNU并不诱导其他神经元包括双极细胞，无长突细胞，水平细胞和节细胞发生凋亡。

MNU intravesical induced bladder tumors in rats , the method is reliable , it is a good way to establish bladder tumor model . 2 .

结论：1.MNU膀胱灌注法诱导建立大鼠膀胱肿瘤模型，方法可靠，成瘤率高，是一种良好的建立膀胱肿瘤模型方法。

Objective To establish the model of bladder tumors in inbred line rats by N-methyl-N-nitrosourea ( MNU ) intravesically .

目的通过膀胱灌注N蛳甲基亚硝基脲（MNU）诱导近交系大鼠膀胱肿瘤。

Repressive effect of the extraction of garlic to the mutagenicity of ENNG and MNU

大蒜提取液对ENNG和MNU致突变作用的抑制效应研究

The orthotopic rat bladder cancer were induced in femal Wistar rats by intravascular administration of the carcinogen , MNU .

大鼠膀胱肿瘤的诱导：雌性Wistar大鼠，通过MNU2.5mg膀胱灌注诱导肿瘤，每两周一次，共4次。

Objective To investigate the mechanism of the toxic effect of N-methyl-N-nitrosourea ( MNU ) on photoreceptor cell apoptosis of rat ′ s retina .

目的探讨N-甲基-N-亚硝脲（MNU）对大鼠视网膜光感受器细胞毒性作用的机制。

AIM : To observe the protective effect of Astragalus injection on N-methyl-N-nitrosourea ( MNU ) - induced photoreceptor apoptosis in SD rats .

目的观察黄芪注射液对N甲基N亚硝脲（MNU）诱导SD大鼠视网膜光感受器细胞凋亡的保护作用。

Aim To study the protective effect of ligustrazine against photoreceptor cell injury induced by N-methyl-N-nitrosourea ( MNU ) in Sprague-Dawley ( SD ) rats .

目的探讨川芎嗪对N-甲基-N-亚硝基脲（NmethylNnitrosourea，MNU）致大鼠视网膜损伤的作用。

Theoretical and Experimental Study on DNA Cross-Linking Induced by Two Nitrosoureas ; Pathological Features and Ultrastructure of N-methyl-N-nitrosourea ( MNU ) - induced Thymic Lymphomas in Mice

N-甲基亚硝基脲诱导胸腺淋巴瘤病理形态学及超微结构研究

In the fourth part of our study , we establish the xenografts of MNU induced tumor in nude mice , then evaluate the effect of ICT on xenografts growth .

第四部分，建立MNU诱导小鼠胸腺T细胞淋巴瘤的裸鼠异种移植瘤模型，研究ICT对移植瘤的作用。

The result is that the extraction of garlic signally repressed mutagenicity of ENNG and MNU , and the repressive rates even reached 83 % .

结果表明，大蒜提取液对ENNG、MNU的致突变性有明显的抑制作用。抑制率可高达83%，并有较好的剂量反应关系。

Aim To study the effect of non-mitogenic human acidic fibroblast growth factor ( nm-haFGF ) on retinal injury induced by N-methyl-N-nitrosourea ( MNU ) in Sprague-Dawley rats and its mechanism .

目的研究非促分裂haFGF（nmhaFGF）对N甲基N亚硝脲（MNU）所致大鼠视网膜损伤的保护作用及其作用机制。

Mutant lines lacking the seed storage glutelin α _2 subunit were obtained from the progenies of fertilized egg cells treated with N_methy_N_ nitrosourea ( MNU ) .

受精卵的甲基亚硝基脲（MNU）处理后代，获得9个谷蛋白α2亚基减少（α2L）突变体。

The paper is composed of three parts : ( 1 ) reasonable verification of the techniqnes ; The analysis of the adducts is carried out after hydrolysis of MNU - DNA adduct .

主要包括如下内容：（1）后桥系统噪声控制措施的合理论证；加合物在水解后分析。

Variance of VEGF expression of photoreceptor damaged by MNU in rats at different time points Other scientists are studying implants in the retina , the light-sensing tissue at the back of the eye .

MNU诱导的视网膜光感受器细胞损伤过程中视网膜VEGF表达的变化其他科学家正在研究视网膜植入法。视网膜是眼后部的光敏组织。

Objective To observe the protective effects of Ginaton ( Gin ) and Puerarin ( Pue ) on N-methyl-N-nitrosourea ( MNU ) - induced retinal degeneration in SD rats and to explore its mechanisms .

目的观察金钠多（Ginaton，Gin）和葛根素（Puerarin，Pue）对N-甲基-N-亚硝脲（N-methyl-N-nitrosorea，MNU）诱导SD大鼠视网膜变性的保护作用及机制。

Objective : To establish the model of retinal injury induced by N-methyl-N-nitrosourea ( MNU ) in Sprague - Dawley rats , then observe the apoptosis of the photoreceptors and the change of the biological characteristics of M ü ller cells .

目的：建立N-甲基-N-亚硝脲（N-methyl-Nnitrosourea，MNU）损伤视网膜的模型，研究视网膜神经元凋亡对Müller细胞生物学特性的影响及神经营养因子的表达变化。

Objective To observe the changes of nuclear factor - κ appa B ( NF - κ B ) in the course of N-methyl-N-nitrosourea ( MNU ) - induced apoptosis of rat retinal photoreceptor cells and investigate the mechanism of MNU-induced retinal damage .

目的观察核因子κappaB（NF-κB）在N-甲基-N-亚硝脲（MNU）诱导大鼠视网膜光感受器细胞凋亡中的的变化，探讨MNU损伤视网膜的机制。

Methods Thirty 50-day-old female Sprague-Dawley ( SD ) rats were intraperitoneally injected with MNU ( 60 mg / kg ) and were put to death by dislocation of cervical vertebra 12 , 24 , 48 , and 72 hours and 7 days after the injection , respectively .

方法将生后50d的雌性SD大鼠30只分别按60mg/kg的剂量一次性腹腔注射MNU。在注射MNU12、24、48、72h和7d后，颈椎脱臼法处死大鼠，取出眼球，做病理切片。