Cefpirome

Stability of cefpirome sulfate in five conventional infusions

硫酸头孢匹罗与5种常用输液配伍的稳定性

To analyse the effect factor of cefpirome sulfate into endotoxin test .

目的：分析硫酸头孢匹罗细菌内毒素检查的影响因素。

To establish a method for sterility of Cefpirome Sulfate for Injection .

建立注射用硫酸头孢匹罗的无菌检查方法。

The validated method can be used to test for sterility of Cefpirome Sulfate for Injection .

采用验证过的试验方法进行注射用硫酸头孢匹罗的无菌检查可行。

Study on of β - lactamases Stability of Cefpirome , a New Fourth Generation Cephalosporin

新四代头孢菌素β-内酰胺酶稳定性的研究

A randomized controlled study on cefpirome versus ceftazidime in the treatment of bacterial infections

头孢匹罗与头孢他啶注射剂治疗细菌性感染的随机对照研究

Objective : To establish an HPLC method for detection of the Cefpirome Sulfate ′ s content and related substances .

目的：建立硫酸头孢匹罗含量及其有关物质的HPLC检测方法。

Methods : Review the effect factor of cefpirome sulfate into endotoxin test from analyzing its acidity and its related impurity .

方法：通过对其酸度以及有关物质的分析，考察了其对细菌内毒素检查的影响因素以及排除其干扰的最佳方法。

Results No allergy reactions , the hemolysis and significant stimulation on vessels and muscles were observed after using cefpirome sulfate .

结果注射用硫酸头孢匹罗对动物无变态反应、无溶血现象，对静脉血管、肌肉无刺激性反应。

A good example of C-3 modification is cefpirome , a representative example of the fourth-generation cephalosporins .

头孢匹罗正是C-3位改造的成功范例，它以其优良的性能成为第四代头孢菌素类抗生素的代表。

Conclusions : Related impurity of cefpirome sulfate is the mostly effect factor , but the interference of related impurity can be eliminated from adjusting its acidity .

结论：硫酸头孢匹罗中的杂质是对细菌内毒素检查产生干扰的主要因素，而调节其供试品溶液的酸度可以有效地排除杂质所带来的干扰。

Objective The enzymatic stability of cefpirome to β - lactamase extracts taken from 8 both plasmid and chromosome-mediated β - lactamases producing strains was studied , and compared with the other four cephalosporins .

目的研究第四代注射用头孢菌素头孢匹罗对8株包括质粒介导与染色体介导产酶菌株β-内酰胺酶的稳定性，并与其它4种头孢菌素进行比较。