ADME

In Vitro Models Used to Screen for Human ADME Drug Properties

药物体外ADME筛选模型

Studies on the ADME / Tox Characteristics of Xiao Chai Hu Tang in Caco-2 Cell Model

小柴胡汤基于Caco-2细胞模型的ADME/Tox特征研究

Traditionally , ADME / T did not draw enough attention , resulting in high failure rate of drug candidates in clinical trials .

传统的药物设计中对ADME/T性质的重视不够，导致候选药物在临床试验阶段失败率极高。

Theoretically predicting the ADME / T properties of drug candidates can improve the success rate of drug development and reduce spending and time wasted .

因此，在药物研发初期就考虑ADME/T性质将会有助于提高候选药物的成功率，从而减少药物开发的时间和金钱上的浪费。

Structural descriptors , descriptors related to ADME and the ligand-receptor binding free energy were calculated to characterize compounds .

在此基础上计算了ADME性质相关的描述符、基于配体-受体相互作用的描述符等对小分子结构进行表征。

High throughput techniques and computer models are widely used in the absorption , distribution , metabolism , excretion , and toxicity ( ADME / Tox ) studies of drugs .

无机物的吸收、分配、代谢和排除以及毒性（ADME/Tox）研究在药物和毒物研究中非常重要。

With the increasing exploitation of new medicaments , absorption , distribution , metabolism , excretion and toxicity ( ADME / T ) of drugs in vivo have been attached importance to .

随着新药的不断开发，药物在生物体内的吸收、分布、代谢、排泄和毒性（ADME/T）等性质已经引起了人们的高度重视。