醛糖

维生素C对糖尿病大鼠肾脏醛糖还原酶活性的影响

Effects of Vitamin C on Activity of Aldose Reductase in Renal Cortex of Diabetic Rats

醛糖还原酶基因启动区C（-106）T多态性与糖尿病视网膜病变相关性研究

Relationship between C ( - 106 ) T Polymorphism of Aldose Reductase Promoter Region and Diabetic Retinopathy

醛糖还原酶抑制剂对糖尿病大鼠肾小球蛋白激酶C活性的影响

The Effection of Aldose Reductase Inhibitors on the Activity of Glomerulus Protein Kinase C ( PKC ) of Diabetic Rat

醛糖还原酶基因（AC）n二核苷酸串联重复序列不同等位基因的筛选

Screening of all types of alleles of ( A-C ) n dinucleotide tandem repeat sequence of aldose reductase gene

醛糖还原酶（AR）在糖性白内障和其它糖尿病并发症的发病中起着关键性的作用。

Aldose reductase ( AR ) plays an important role in sugar cataract and other complications of diabetes .

醛糖还原酶cDNA转染的CHO细胞株的建立及其基因表达与生化特性

The establishment of CHO cell line transfected with aldose reductase cDNA , its gene expression and biochemical characters

醛糖还原酶抑制剂对链脲霉素糖尿病小鼠眼晶状体代谢影响、ATP酶及抗氧化性防御的评价：一项干预性研究

Evaluation of an aldose reductase inhibitor on lens metabolism , ATPases and antioxidative defense in streptozotocin-diabetic rats : an intervention study

此外小组确定，给注入人结肠腺癌细胞的小鼠以醛糖还原酶小片段干扰RNA能够完全阻止肿瘤的发展。

In addition , the team established that administration of aldose reductase small interfering RNA to mice bearing human colon adenocarcinoma cells completely arrested tumor progression .

目的找出优化NADP生成荧光法测定红细胞醛糖还原酶（AR）活性的方案。

Objective To optimize the the NADPgenerating fluorimetric method for aldose reductase ( AR ) activity .

实验结束时，观察5药对D-半乳糖诱导大鼠体内醛糖还原酶（AR）活性、糖耐量和蛋白非酶糖基化反应的作用。

In the end experiment , glucose tolerance , products of protein glycation and the activity of aldose reductase in red blood cells were determined .

目的研究中药巴戟天对晶状体醛糖还原酶（AR）的抑制作用，以期找到一种治疗糖性白内障的中药。

Objective To study the inhibitory effect of Radix Morindae Officinalis on lens aldose reductase in the hope of finding a traditional medicinal herb to control diabetic cataract .

人醛糖还原酶基因酵母表达模型的构建及ARI抑制AR活性的初步观察

Construction of a Model for Human Aldose Reductase Functional Expression in Saccharomyces Cerevisiae : Application for the Evaluation of ARI on AR Activity

目的观察中药复方筋脉通对糖尿病大鼠坐骨神经传导速度、坐骨神经组织和红细胞内醛糖还原酶活性（AR）及山梨醇（SNS）浓度的影响，并探讨其作用机理。

Objective To investigate the effects of Jin Mai Tong ( JMT ) on nerve conduction velocity , aldose reductase activity and sorbitol in diabetic rats .

目的观察醛糖还原酶（AR）基因转染对体外培养大鼠肾脏系膜细胞（MsC）增殖的影响，并对其机制进行初步探讨。

Objective To study the effects of aldose reductase ( AR ) on the proliferation of rat mesangial cells ( MsC ) in vitro and to investigate its mechanism .

方法体外培养的人脐静脉内皮细胞，采用RT-PCR、生化测定等方法检测醛糖还原酶（AR）活性及mRNA表达。

Methods Human umbilical vein endothelial cells ( HUVECs ) were cultured in vitro . The activity of AR gene expression in mRNA level in HUVECs were measured by RT-PCR and biochemical assay .

目的：探讨银染法检测醛糖还原酶（aldosereductase，AR）基因5′端微卫星多态性的可靠性。

Objective : To explore the reliability of silver stain determination of the microsatellite polymorphism at 5 ′ end of aldose reductase ( AR ) gene .

目的构建由绿色荧光蛋白（GFP）标记的糖尿病慢性并发症相关基因醛糖还原酶（AR）表达载体，并在酵母细胞中表达，建立AR抑制剂筛选模型。

Objective By constructing the expression vector of aldose reductase ( AR ) fused with the green fluorescent protein in Saccharomyces cerevisiae cells to set up AR inhibitor screening model .

第三章对吲哚乙酸类醛糖还原酶抑制剂进行了3D-QSAR和分子对接研究。

The 3rd chapter , 3D-QSAR and molecular docking studies on indoleacetic aldose reductase inhibitors .

目的：制备抗醛糖还原酶相似蛋白（aldosereductaselikeprotein，ARL-1）的单克隆抗体（mAb）并进行初步应用。

AIM : To prepare monoclonal antibodies against aldose reductase - like ( ARL - 1 ) protein .

雄性Sprague－Dawey大鼠，用乌拉坦（70mg/kg）和氯醛糖（30mg／kg）腹腔麻醉。

Experiments were Performed on male SD rats anaesthetized with urethane ( 700 mg / kg ) and chloralose ( 35 mg / kg ) .

结论cDNA芯片分析发现：转染醛糖还原酶相似基因1后肝癌细胞的基因表达谱发生改变，为系统研究肝癌的耐药性及其机制提供了有益的线索。

Conclusions cDNA chips showed that gene expression profile of liver carcinoma cell was changed after transfection of the ARL-1 gene . It is a useful method in understanding the mechanism of drug resistance .

为从大量中草药及其化学成份中筛选有效低毒的醛糖还原酶抑制剂（ARI），建立了猪晶状体AR的测定方法，其研究了知母等40种中药水提取液对AR的抑制作用。

For screening aldose reductase inhibitors ( ARI ) from traditional medicinal herbs , the assay method of pig lens AR was established and 40 traditional medicinal herbs were screened .

目的：研究山茱萸醇提液对D-半乳糖致衰大鼠体内非酶糖化和醛糖还原酶活性（AR）的影响。

Objective : To study the influence of medicinal cornel extract by alcoholic extraction on intrinsic protein glycosylation without enzyme catalysis and aldose reductase ( AR ) in ageing white rat caused by D-galactose .

目的：观察不同麻醉方法对胃癌手术患者红细胞醛糖还原酶（AR）活性及血浆一氧化氮（NO）浓度的影响。

Objective : To investigate the effects of different anesthesiaes o n the activity of aldose reductase ( AR ) in RBC and the level of plasma nitric oxid e ( NO ) in patients undergoing gastric cancer operation .

糖尿病大鼠肾脏醛糖还原酶活性变化对TGF-β1mRNA表达的影响

Effect of activity of aldose reductase on the expression of TGF - β _1 mRNA in rats with streptozotocin-induced diabetes

研究了醛糖还原酶抑制剂Tolrestat对高浓度葡萄糖（HG）所致肾小球系膜细胞（MC）肌动蛋白（actin）组装的影响。

The effect of Tolrestat , an aldose reductase inhibitor , on high glucose-induced actin disassembly in rat glomerular mesangial cells ( MC ) was quantitatively studied using dual fluorescence labeling technique and confocal laser scanning microscopy .

原发性高血压患者醛糖还原酶活性改变及其编码基因的C-106T多态性

The Change of the Aldose Reductase Activity and the C-106T Polymorphism of Aldose Reductase Gene in Essential Hypertension

目的：观察醛糖还原酶抑制剂（ARI）对糖尿病早期大鼠角膜组织中醛糖还原酶活性（AR）、钠-钾-ATP酶活性（Na+-K+ATPase）和角膜病变的影响，并探讨其防治效应及其机制。

OBJECTIVE : To observe the effect of aldose reductase inhibitor ( ARI ) on the activity of corneal aldose reductase ( AR ) and Na + - K + ATPase , and on corneal lesions in early diabetic rats and to investigate the protective mechanism .

目的检测小鼠ARL-1同源蛋白的表达情况，分析人醛糖还原酶相似基因（ARL-1）与小鼠ARL-1同源蛋白的同源性和遗传距离，从进化的角度讨论小鼠ARL-1同源蛋白与人ARL-1的亲缘关系。

Objective To detect expression of mouse ARL-1 homologous proteins in mouse tissues , and analyze homology , genetic distance and phylogenetic relationship between human aldose reductase like-1 ( ARL-1 ) and mouse homologous proteins .

微波辐射下活性MnO2选择氧化苯甲醇合成苯甲醛转酮醇酶是磷酸戊糖途径的关键酶，催化二碳单元在酮糖（体）醛糖（体）的转移。

Synthesis of Benzaldehyde from Benzyl Alcohol by Selective Oxidation with Active MnO_2 Under the Microwave Irradiation Transketolase is the key enzyme of pentose-phophate pathway , catalyses transfer of a two-carbon fragment from a ketolase ( donor substance ) to an aldose ( acceptor substance ) .