表观遗传学

组蛋白乙酰化修饰是表观遗传学中的重要组成部分，组蛋白乙酰化酶（HAT）和组蛋白去乙酰化酶（HDAC）之间的动态平衡控制着染色质结构和基因表达。

Histone acetylation is an important part of epigenetics . The dynamic equilibrium between Histone acetyltransferase ( HAT ) and histone deacetylase ( HDAC ) can control the chromatin structure and gene expression .

认为中国应加大表观遗传学研究领域投入，拓宽研究领域并加强与其他机构和国家的合作。

It considers that China should increase the investment in epigenetics , expand research field and enhance cooperation with other institutions and countries .

DNA甲基化是白血病表观遗传学改变中较常见的改变。

DNA methylation is a frequent change in epigenetics of leukemia .

DNA甲基化是最常见的表观遗传学改变。

DNA methylation is one of the most frequent epigenetic alterations .

应用表观遗传学方法探索孕妇血浆中胎儿游离DNA

Method of application of epigenetics in maternal plasma of free fetal DNA

病毒SET蛋白对细胞基因的表观遗传学阻遏&一种可能的基因沉默新技术

Epigenetic repression of cellular genes with viral SET protein & a kind of new possible technique causing transcriptional silencing

DNA甲基化&肿瘤产生的一种表观遗传学机制

DNA Methylation : An Epigenetic Mechanism for Tumorigenesis

在真核生物中，DNA甲基化修饰是调控基因表达的一个重要的表观遗传学标志。

DNA methylation is an important epigenetic mark forthe regulation of gene expression in eukaryotes .

DNA甲基化作为一种表观遗传学修饰，是调节基因表达的一种重要方式。

As an epigenetic modification , DNA methylation is an important way to regulate gene expression .

在治疗学上它意味着预防氧化应激可以中止DNA的表观遗传学改变。

Therapeutically , it may mean that preventing oxidative stress may stop epigenetic changes in DNA .

表观遗传学研究那些非DNA序列决定的遗传特性。

Epigenetics examines the inheritance of characteristics that are not set out in the DNA sequence .

表观遗传学：生物细胞非编码RNA调控的研究进展

Epigenetics : advances of non-coding RNAs regulation in mammalian cells

表观遗传学是研究DNA序列没有发生改变的情况下基因表达的遗传变化。

Epigenetics is defined as the investigation of heritable changes in gene expression that occur without a change in DNA sequence .

DNA甲基化（DNAMethylation）是真核生物基因组最常见的一种DNA共价修饰形式，是表观遗传学的一个重要方面。

DNA methylation is a usual covalent modification in eukarya genome and is an important part of epigenetics .

DNA甲基化是表观遗传学修饰的一个重要内容，在早期胚胎发育中起重要的调节作用。

DNA methylation is one of important aspects in epigenetic modifications and plays an important role in regulation of early embryo development .

其中一种表观遗传学因素涉及甲基化过程中被加在DNA上的“分子帽子”。

One type of epigenetic factor they looked at involved molecular caps that are placed on DNA in a process called methylation .

近年来随着表观遗传学研究的兴起，研究者发现DNA甲基化在基因组中含量丰富、分布广泛，并且与年龄之间存在紧密的相关性。

In recent years , learners of epigenetics found that DNA methylation was widely distributed , and had strong correlation with age .

细胞衰老过程中P53表观遗传学修饰

Epigenetic modifications of P53 during cellular senescence

这些研究表明神经激活介导的DNA甲基化状态改变由可能是成体神经系统中一种重要的表观遗传学调控机制。

Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system .

表观遗传学是近年来新兴起的生物学学科，主要研究在没有DNA序列改变情况下基因功能可逆的、可遗传的变异。

Epigenetic is the latest biological science in recent years , which mainly researches gene function reversible and heritable variation without DNA sequence changes .

最引人注目的发现是意味着DNA改变的表观遗传学变化的存在，而且这种改变会持续很长一段时间。

The most striking finding was the presence of epigenetic changes meaning that the DNA is altered and this alteration lasts for long periods .

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

Epigenetic mechanisms , including DNA methylation , histone modification and chromatin remodeling , have been demonstrated to be involved in the development of SLE .

表观遗传学包括DNA甲基化、组蛋白修饰以及由非编码RNA调控的mRNA表达等。

Epigenetic mechanisms include DNA methylation , histone modifications such as acetylation and methylation , and control of mRNA expression by non-coding RNAs .

表观遗传学指不发生DNA序列改变的基因表达改变，DNA甲基化和组蛋白修饰是其中的两个主要内容。

Epigenetics refers to gene expression changes which DNA sequence will not changed , the main contents of epigenetic mechanism is that DNA methylation and histone modification .

系统性红斑狼疮（SLE）的表观遗传学发病机制研究进展

The Epigenetic Pathogenesis of Systemic Lupus Erythematosus

表观遗传学指的是DNA的功能不取决于编码DNA的序列本身而是在于影响DNA的辅助分子和机制。

Epigenetics refers to the function of DNA that does not depend on the coding DNA sequence itself but on the accessory molecules and mechanisms affected by DNA .

表观遗传学（epigenetics）是指在DNA序列没有发生变异的情况下，基因表达的可遗传改变；

Epigenetics refers to changes in gene expression that do not entail a change in DNA sequence .

卵巢癌（ovariancancer，OC）是妇科肿瘤中致死率最高的肿瘤，严重威胁妇女的健康和生命。表观遗传学在卵巢癌研究中的进展越来越引起重视。

Ovarian cancer is the highest mortality gynecological cancer , which has a serious threat to the health and lives of women .

同时，表观遗传学修饰，如DNA甲基化，被认为在许多种恶性肿瘤中广泛存在。而亚洲大肠癌患者的甲基化状态仍有待进一步研究。

Epigenetic modifications , such DNA methylation , have also been implicated in many cancers but have yet to be examined in the East Asian population of colorectal cancer patients .

研究发现，母亲孕期吸烟，孩子在DNA甲基化上表现出差异，DNA甲基化是一种表观遗传学机制，在这个过程中化学小分子添加到DNA上。

The study found that children exposed in the womb to maternal smoking had differences in DNA methylation , an epigenetic mechanism in which small chemical compounds are added to DNA .