血管发生

研究背景及目的内皮祖细胞（EPCs）是胚胎发育早期参与血管发生（Vasculogenesis）的最重要的干细胞，近年研究发现成人骨髓和外周血中也存在少量EPCs。

Background and Objective Endothelial Progenitor cells ( EPCs ), one of the most important stem cells participated in vasculogenesis at the early stage of embryo development , were recently found in adult bone marrow and peripheral blood .

它们不仅参与胚胎时期的血管发生，也存在于成年体内的骨髓和外周血中，参与血管的修复和新生。

EPCs can not only participate in vasculogenesis in embryonic period but also contribute to vascular repair and neovascularization .

鸡胚尿囊膜（CAM）是研究体内血管发生的重要模型之一。

Objective To investigate the antiangiogenesis effect of cryptotanshinone on chick embryo chorioallantoic membrane ( CAM ) .

卵巢粒层细胞瘤中PCNA表达及血管发生的意义

Significance of PCNA Expression and Angiogenesis in Granulosa Cell Tumor of Ovary

而内皮细胞生长因子（VEGF）在视网膜和脉络膜新生血管发生中起着关键作用。

Endothelial growth factor ( VEGF ) in retinal and choroidal neovascularization play a key role in the occurrence .

结论SAD可使大鼠的心、肾和血管发生类似于高血压靶器官损伤的病理改变。

CONCLUSION SAD can lead to cardiovascular and renal morphological changes that are similar to target organ damage in hypertension .

此前还没有发现可以影响VEGF通路或调节血管发生过程的个别的微小RNA，RNA可通过滴定细胞产生的特定蛋白水平来确定。

Individual microRNAs , which titrate the level of specific proteins generated by the cell , were not previously known to affect VEGF signaling or regulate angiogenesis .

目的：克隆人血管发生抑制因子restin（hRS），在E。

Objective : To clone human angiogenesis inhibitor restin ( hRS ), express fusion protein in E.

结论肝癌Ang-2和VEGF的共同表达能诱导肿瘤血管发生，并且和肝癌的入侵与恶性程度以及和疾病预后有关。

Conclusion Expression of Ang-2 and VEGF simultaneously could induce angiogenesis of HCC , and had obvious relation with the invasion , malignancy and prognosis of HCC .

去甲二氢愈创木酸（NordihydroguaiareticAcid，NDGA）作为一种特异性的脂氧化酶（lipoxygenase，LOX）抑制剂，具有抑制肿瘤及非肿瘤血管发生作用。

Nordihydroguaiaretic acid ( NDGA ), as a specific inhibitor of lipoxygenase ( LOX ), is responsible for the inhibition of tumorous and nontumorous angiogenesis .

HIF-1具体调节的靶基因涉及到红细胞的生成、血管发生、能量代谢、激素代谢等各方面，反映出机体对低氧的适应调节能力。

HIF-1 can regulate target gene related to the production of erythrocyte , angiogenesis , energy metabolism , hormone metabolism , etc , underlining the adaptive ability of organizations to hypoxia .

结论：Cox-2在膀胱癌中均为高表达，它的表达参与了肿瘤的发生及恶性进展，并且与膀胱肿瘤新生血管发生有着密切关系。

Conclusions : Cox-2 has a strong expression in the bladder neoplasms . The expression of it involved in the occurrence and progression of the cancer , as well as in the tumor angiogenesis .

急性脑梗死（Acutecerebralinfarction，ACI）患者颅内动脉血管发生血栓形成，是否也存在凝血和纤溶异常，正越来越多受到许多学者的关注。

Acute cerebral infarction ( ACI ) refers to the tissue damage that results from intracranial artery thrombosis . More and more experts lay emphasis on whether there are some abnormalities in coagulative and fibrinolytic system in patients with acute cerebral infarction .

同时，也有研究人员发现跑步训练提高了脑源性神经营养因子（BDNF）和其它生长因子的水平，突触活动也变得活跃，代偿地引起血管发生，脑血管密度增加。

Some studies have also indicated that running exercise increases levels of BDNF and other growth factors , enhances synaptic activity , elicits compensatory angiogenesis and increases the density of blood vessels .

高糖通过PI3K-Akt信号途径抑制内皮细胞迁移和增殖及血管发生改变

High D-glucose alters PI3K and Akt signaling and leads to endothelial cell migration , proliferation and angiogenesis dysfunction

PTHrPKI也造成了脑细胞迁移、分化和成熟的延迟及髓鞘形成和脑血管发生异常。

PTHrP KI was also resulted in the delay of the migration , differentiation and maturation of neural cells and the impairment of myelin formation and brain angiogenesis .

这些发现充分说明PTHrP的NLS和C-末端可通过促进脑细胞增殖、迁移、分化、血管发生和抑制脑细胞凋亡而在小鼠脑发育中起重要作用。

Our findings indicate that the PTHrP NLS and carboxyl terminus play important roles in brain development by stimulating neural cell proliferation , migration , differentiation and angiogenesis and by inhibiting neural cell apoptosis .

CARP具有多种功能，在血管发生，心脏发育，细胞凋亡，转录调控，纤维的装配和拉伸传感，核质通讯等方面具有重要作用。

As a multifunctional factor , the information on the molecular functions of CARP suggests that the gene plays a critical role in angiogenesis and vasculogenesis , cardiac development , transcriptional regulation , myofibrillar assembly , stretch sensing , and in communication between the sarcoplasm and the nucleus .

本试验的主要目的是来探讨在视网膜新生血管发生的过程中缺氧诱导因子（HIF）与血管内皮生长因子（VEGF）表达变化规律及他们之间的表达关系。

Firstly , the main purpose of this study is to investigate the the process of hypoxia-inducible factor ( HIF ) and vascular endothelial growth factor ( VEGF ) expression changes and the expression of the relationship between them in occurrence of retinal neovascularization .

GICD实验室的研究主管医学博士迪派克。斯里瓦斯他瓦发现了一个微小的RNA分子miR-126密切参与了血管发生信号引起的血管反应。

Researchers in laboratory of GICD Director Deepak Srivastava , MD , found that microRNA ( miR-126 ), a tiny RNA molecule , is intimately involved in the response of blood vessels to angiogenic signals .

位于其深部组织内的小血管发生栓塞。

Thrombosis occurs in the small vessels of the underlying tissue .

子宫内膜异位症在位与异位子宫内膜血管发生研究

Study on Angiogenesis of Eutopic and Ectopic Endometrium in Endometriosis

结论缺氧是视网膜新生血管发生的主要原因；

Conclusion Hypoxia is the main reason of occurrence of retinal neovascularization ;

血管发生是指血管发育的的过程，是一个精细调控，已经被研究的很透彻。

Angiogenesis , the process of vascular development , is a tightly regulated and well-studied process .

HGF/c-Met通路促进肿瘤细胞的生存和生长，并且在血管发生和转移中起重要作用。

HGF / c-Met pathway also contributes to survival , angiogenesis , metastasis and growth of tumor .

相应的，如果缺血性卒中后期，责任血管发生再通或者是侧支循环建立恢复供血，又会面临着缺血再灌注损伤。

When responsible vascular recanalization or collateral circulation restores the blood supply , it will face ischemia-reperfusion injury .

结果观察病例中病理性近视黄斑区视网膜下新生血管发生的构成比为30.6%。

RESULTS Ratio of subretinal neovascularization found in macular zone of the patients with pathological myopia was30.6 % .

背景与目的：肿瘤的血管发生与肿瘤的生长关系密切。

BACKGROUND AND OBJECTIVES : There is an intimate relationship between the angiogenesis of tumors and the growth of tumors .

但是近年来的临床和基础研究发现糖尿病患者和动物模型在视网膜特征性微血管发生改变以前已经出现了神经元的改变。

Recently clinical and preclinical study indicated that neurodegeneration happened earlier than capillary vessel changes in the retina of diabetic patients and animal model .

近年来研究表明，该蛋白除了在骨形成、血管发生等生理过程中发挥重要功能外，在肿瘤发生发展等病理过程中亦有着重要作用。

Recent publications showed that OPN play important roles not only in physiological processes such as bone formation and angiogenesis , but also in oncogenesis .