细胞信号传导通路

姜黄素对乳腺癌MCF-7细胞信号传导通路相关蛋白激酶的调节作用

Regulation of Protein Kinases on Signal Pathway in Breast Cancer Cell MCF-7 by Curcumin

p53是一个重要的肿瘤抑制基因，p53介导的细胞信号传导通路途径在调节细胞正常生命活动中起重要作用。

P53 is a very important tumor suppressor gene , and cell signal transduction pathway mediated by p53 play an important role in regulating the normal activities of cells .

蛋白激酶C（proteinkinasec，PKC）是一组具有单一肽链结构的丝氨酸／苏氨酸蛋白激酶，是机体细胞信号传导通路的中心环节，广泛分布于中枢神经系统。

Protein kinase C ( protein kinase C , PKC ) is a serine / threonine protein kinase with a single peptide chain structure , which is the central link of the body cell signaling pathways , widely distributed in the central nervous system .

Ras-MAPK途径是细胞信号传导通路中一条重要途径。

Ras / MAPK way is an important way in the cells signal conduct pathway .

结论TNF-α可导致BBB通透性增高，Rho/Rhok细胞信号传导通路可能参与此过程的调控。

Conclusion ( TNF - α) can increase the BBB permeability , and the Rho / Rhok signaling pathway is involved in the regulation of BBB permeability induced by ( TNF - α) .

涉及神经元一氧化氮合酶细胞信号传导通路

involves the cellular signaling pathway of neuronal nitric oxide synthase .

作用于细胞信号传导通路的抗肿瘤中药研究进展个性话机留言

Research Advance of Anti-tumor Materia Medica Acting on Cellular Message Transmission Pathway

主要研究任务：免疫细胞信号传导通路分子机制的研究。

Main task : Study the immune-related signaling pathway .

癌基因和抑癌基因的发现，细胞信号传导通路的阐明，极大地丰富了人们对细胞癌变机制的认识。

The discovery of oncogenes and tumor suppressor genes , and the research of signal transduction pathway yield profound insights into the mechanisms of carcinogenesis .

文章从细胞信号传导通路、细胞生存途径、基因治疗及血管生成四方面简要介绍这些新靶点和已经或正在研发的新药物。

This review briefly focused on the new targets and agents from the following four aspects : signal transduction pathway , cell survival pathway , gene therapy , and angiogenesis .

细胞信号传导通路的异常激活在促进肿瘤细胞生长、增殖，促进细胞运动、侵袭，抑制细胞凋亡，抵抗化疗和放疗的过程中起重要作用。

Aberrant activation of cell signaling pathway has been associated with proliferation , inhibitory apoptosis , invasive growth and metastasis of tumor cells as well as their elevated resistants to radiation and chemotherapy .

从树突状细胞Toll信号传导通路探讨肝癌发生的分子机制

The Study on the Molecular Mechanism of Hepatocellular Carcinoma Pathogenesis from Toll Signaling Transduction Pathway in Dendritic Cells

TGFβ2和ECM的这种调节作用可能是通过PKC细胞内信号传导通路而发挥作用。

These mediated effects of TGF β _2 and ECM may act via the PKC signal transduction pathway .

细胞通过信号传导通路将来自细胞外各种刺激传导入细胞核内，调节基因的表达，从而使细胞产生增殖、分化、凋亡等生命活动。

A plethora of extracellular stimuli were transmitted into the nucleus through signal transduction pathway .

众多学者对胃泌素发挥生物作用的细胞内信号传导通路进行了广泛而深入的研究。

Many scientists have studied deeply and extensively the intracellular signal transduction pathway through which gastrin exerts the biological effects .

因而本实验结果强烈提示这种靶向抑制干细胞的信号传导通路的策略能够成功的应用到肿瘤的治疗中去，为临床治疗肿瘤奠定了基础。

The strategy described here strongly suggests that specific targeted inhibition of stem cell signaling pathways could be applied to cancer therapy .

EGFR同相应的配体结合形成同源或异源二聚体，从而激活细胞内下游信号传导通路。

Upon binding to corresponding ligands . the EGFR forms homo-or heterodimers and activate downstream signal transduction pathways .

结论MAPK可能是EGF刺激RA滑膜细胞增生的信号传导通路中的重要介质。

Conclusion MAPK is likely to recepter an important component in the cascade of signals that link EGF receptor to EGF eliciting the cellular proliferative response in rheumatoid synovial fibroblasts .

很多细胞内的信号传导通路是由受体型酪氨酸蛋白激酶（RPTK）调控的，这些通路可以控制细胞的生长、分化和新陈代谢等不同功能。

Receptor protein-tyrosine kinases ( RPTKs ) are tightly regulated during normal cellular signal transduction processes including cell growth , differentiation , and metabolism .

内皮祖细胞与PI3K/Akt信号传导通路

Endothelial Progenitor Cells and PI3K / Akt Signal Transduction Pathway

细胞凋亡的信号传导通路及相关因子研究进展

Signal transduction pathways and the relative factors of apoptosis

深入研究调控破骨细胞活化的信号传导通路对于阐明正畸治疗骨改建的机理十分必要，但目前有关力学刺激调控破骨细胞分化的信号传导机制尚未完全清楚，有待进一步研究。

It is necessary to understand the regulatory mechanism of signals transduction in osteoclast activation by mechanical stimuli .

碘化钾与铅对近曲肾小管上皮细胞HK-2中信号传导通路及细胞凋亡的影响

Effect of Kalium Iodidum and Lead to Apoptosis and Cellular Signal Transduction in Proximal Renal Tubular Cell HK-2

这提供了一个理论依据，即在大脑损伤或创伤后，改变神经细胞特定的信号传导通路能预防患者癫痫发作的科学基础。

This provides a'proof of concept'that altering specific signaling pathways in nerve cells after a brain insult or injury could provide a scientific basis for treating patients to prevent epilepsy .

弥漫性大B细胞淋巴瘤中PI3K/AKT/mTOR信号传导通路异常及机制探讨

Study on the Alteration of PI3K / AKT / mTOR Signal Pathway and Its Mechanisms in Diffuse Large B Cell Lymphoma

RNA干扰沉寂survivin表达及其对肝癌细胞凋亡和相关信号传导通路的影响

RNAi-Mediated Silencing of Survivin and HBXIP Expressions and Its Effects on Apoptosis and Signal Transduction of Human Cancer Cells

大鼠胃黏膜细胞EGFR通过ERK-1/2信号传导通路激活AP-1

EGFR Activates AP-1 Through ERK-1 / 2 Signaling Pathway in the Rat Gastric Mucosal Cells

体外研究显示，外源锌离子可激活细胞内多个信号传导通路，如表皮生长因子受体（EGFR）等。

The in vitro studies have shown that exogenous zinc ions can activate multiple intracellular signaling pathways , such as EGFR .

结论：嗜酸性粒细胞可通过p38MAPK信号传导通路活化支气管上皮细胞表达MCP-1，调控过敏性气道炎症反应。

CONCLUSION : Eosinophils can activate bronchial epithelial cells to express MCP-1 in co-culture by p38 MAPK pathway so as to regulate the airway inflammatory reaction .

目前国外研究机构对其它肿瘤的研究中已发现IGF-IR与COX-2之间存在相互作用，但目前尚未见国内外有关肾癌细胞IGF-IR、COX-2信号传导通路之间是否存在关系的报道。

These years , research institutes abroad found the relationship between IGF-IR and COX-2 in many tumors . It has not been reported whether the IGF-IR signaling pathway relates to COX-2 in RCC .