溴隐亭

TRH、GRH及溴隐亭对垂体生长激素腺瘤细胞分泌激素的影响

Studies on the response of GH secretion to trh , GRH and bromocriptine in somatotrophinoma cells

随着溴隐亭剂量的增加，血清及子宫组织中IFNγ含量上升，催乳素、孕酮及IL10含量下降。

As the dosage of Bromocriptine increased , the contents of IFN - γ went up but IL-10 , prolactin and progesterone declined in serum and uterus .

而其它4种浓度的溴隐亭溶液对精子功能的影响差异无显著性（P＞0.05）。

The other five concentrations ( 5.0,2.5,1.0,0.5 and 0.1 ) showed no effects on the sperm 's functions .

HPLC法测定甲磺酸溴隐亭片的含量

Determination of Content for Bromocriptine Mesylate Tablets by HPLC

中药治疗溴隐亭致流产大鼠模型PRL分泌机制对母胎界面Th细胞因子的影响

Effect of the Prolactin Secretion of Bromocriptine Induced Abortion Rats on Th Cytokine on Maternal-fetal Interface

中药对溴隐亭致流产模型血清PRL的影响

Effect of Chinese Herbs on Serum PRL in the Rat Model of Bromocriptine Induced Abortion

本文报告5例男性垂体PRL大腺瘤的临床表现及溴隐亭的疗效。

The therapeutic effect of bromocriptine on 5 male patients with pituitary PRL-producing macroadenoma was observed and discussed .

VTA微量注射溴隐亭诱发大鼠睡眠&觉醒的改变

Changes of Sleep & wakefulness Induced by Microinjection of Bromocriptine Into the Ventral Tegmental Area in Rats

15例微腺瘤、6例大腺瘤患者服溴隐亭治疗1~6个月，临床症状均有所改善，而且PRL水平降低50%；

After taking Bromocriptine , clinical symptoms of 15 patients with microadenoma and 6 patients with macroadenoma were improved in 1-6 months , and PRL decreased 50 % ;

目的探讨人肿瘤坏死因子α（TNFα）联合溴隐亭（BCT）对人肝癌裸鼠耐药模型耐药性的逆转作用。

Objective To investigate synergistic effect of bromocriptine ( BCT ) combining tumor necrosis factor - α ( TNF - α) on reversing multidrug resistance in a nude mouse model of liver neoplasm .

补肾中药对溴隐亭致流产鼠模型中蜕膜CD56~+NK细胞表面CD69和CD94表达的影响

Effects of Kidney-Replenishing Herbs on the Expression of CD69 and CD94 on the CD56 ~ + Decidual NK Cells in Improved Bromocriptine-Induced Abortion

[结果]溴隐亭对AA大鼠的胸腺有明显的改善作用（P<0.01），并能够提高淋巴细胞的转化率（P<0.01），降低IL-2的浓度（P<0.05）。

[ Results ] Bromocriptine could improve the thymus of adjuvant arthritis in rats ( P < 0.01 ), increase the turning rates of lymphocyte ( P < 0.01 ) and decrease the concentration of IL-2 ( P < 0.05 ) .

结论对PRL水平增高的患者，应定期监测PRL水平，根据PRL水平找到最佳溴隐亭治疗量，观察治疗效果，防止垂体病变。

Conclusion The patients with increasing serum PRL level should regularly be monitored . The optimal therapeutic dose of Bromocriptine should be determined according to the PRL level for preventing the pituitary gland pathological changes .

溴隐亭的作用包括：抑制泌乳素（Prolactin，PRL）的合成、使垂体腺瘤细胞体积减小、周围血管纤维化和局部细胞坏死，从而使肿瘤体积减小。

The functions of DA include : inhibit the synthesis of prolactin ( PRL ), reduce the pituitary adenoma cell volume , peripheral vessels fibrosis and localized area of cell death , thus decrease the tumor volume .

治疗Ⅱ组：每日经腹腔注射盐酸哌替啶20mg/kg，连用21d后停药改用溴隐亭20mg/次胃饲，连用30d；对照组：经腹腔注射生理盐水与上述同等毫升数，连用21d。

Then 20 mg bromocriptine for one time by gavage was administrated every day , continuously for 30 days Control group : Equal saline was injected intraperitoneally for successive 21 days .

利用体外垂体组织培养技术及灭吐灵诱导HPRL（Hyperprolactinemia，高泌乳素血症）小鼠模型，以溴隐亭为对照，观察敛乳方的作用。

An in vitro system of pituitary tissue culture and a HPRL ( hyperprolactinemia ) mice model induced by metoclopramide were used to observe the effects of BTLD .

结果显示麦芽总提取物高、中、低剂量组均能明显降低雌性小鼠血清泌乳素水平（P0.05），抑制灭吐灵诱导的高泌乳素血症，作用与溴隐亭相当。

The results showed the blood serum PRL of the high , medium and low-dose total malt extract group were significantly decreased , the difference was significant ( P0.05 ), the total malt extract could inhibit HPRL induced by metoclopramide , the effect is similar to the role of bromocriptine .

以上结果表明，多巴胺通过激活多巴胺D2受体产生活性氧物质而引起垂体瘤细胞凋亡，而溴隐亭则可通过受体或非受体两条途径引起细胞死亡。

These data suggest that the dopamine induces apoptosis via dopamine D2 receptors involving oxidative stress and that bromocriptine utilize differential pathway to execute cell death using either D2 receptor - dependent and - independent pathways in pituitary tumor cells .

补肾益气清热方对溴隐亭致大鼠流产模型中垂体PRL-R、PrRP-R表达的影响

Effect of a Traditional Chinese Medicine , Bu-shen , on Expression of Pituitary PrRP-R 、 PRL-R in the Improved SD Rats Model with Bromocriptine-Induced Abortion

溴隐亭治疗高泌乳素血症119例

Treatment of Hyperprolactinemia with Bromocriptine : Analysis of 119 Cases

溴隐亭治疗侵袭性巨大泌乳素腺瘤的长期随访结果

Treatment of invasive giant prolactinomas with bromocriptine : results of long-term follow-up

溴隐亭对小鼠生育的影响及其作用机理

Effect of Bromocriptine and its mechanism on the fertility in the mouse

溴隐亭治疗垂体泌乳素腺瘤的研究进展

The Research Development of Bromocriptine in the Treatment of Prolactinomas

溴隐亭治疗肢端肥大症继发糖尿病与糖耐量异常报告

Secondary diabetes and IGT in the treatment of acromegaly with

溴隐亭对高泌乳血症101例治疗观察

Clinical Observation of 101 Cases of Hyperprolactinemia Treatmented with Bromocriptine

目的：探讨溴隐亭的降糖作用及降糖机理。

OBJECTIVE : To study the hypoglycemic effect and mechanism of bromocriptine .

预测溴隐亭治疗活动性肢端肥大症短期疗效指标的分析

On the criteria predicting the short-term therapeutic effect of bromocriptine on active acromegaly

溴隐亭对离体精子受精能力的影响

Effects of bromocriptine on fertilizing ability of sperm

溴隐亭治疗泌乳&闭经综合征后妊娠的观察（附25例分析）

Pregnancies Following Bromocriptine in Patients with Galactorrhea-Amenorrhea Syndrome ( Analysis of 25 Cases )

溴隐亭治疗异常溢乳合并无排卵（附36例分析）

Bromocriptine in the Treatment of Galactorrhea with Anovulation ( Report of 36 Cases )