氨甲基化

组蛋白上广泛发生的精氨酸甲基化修饰与基因的转录调控，细胞周期调控以及DNA损伤修复等过程都密切相关。

Arginine methylation broadly occurs in histones and has been linked to transcriptional regulation , cell cycle regulation and DNA repair .

组蛋白赖氨酸甲基化作为共价修饰的一种在基因表达调控、X染色体失活、基因组印迹、DNA修补等生物学过程中起重要作用。

Histone lysine methylation has important functions in many biological processes that include gene expression , X-chromosome inactivation , gene imprinting and DNA repair .

组蛋白赖氨酸甲基化研究进展

Advance of histone lysine methylation

组蛋白赖氨酸甲基化在基因表达调控中的作用已成为表观遗传学研究的热点。

The role of histone lysine methylation in the gene expression regulation has turned into the hotspot of epigenetics .

组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。

The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification .

过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。

Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues .

在30年前，人们便发现蛋白甲基化是真核细胞中常见的翻译后修饰方式之一，主要包括精氨酸甲基化和赖氨酸甲基化。

Thirty years ago , many studies showed that protein methylation is the most common type of post-transcription modification in eukaryocyte cells , and it contains arginine methylation and lysine methylation .

在现有的多种组蛋白修饰中，组蛋白赖氨酸的甲基化实际上参与了所有的以染色质为基础的生物进程，包括转录调控和DNA损伤修复。

Among various histone modifications identified , histone lysine methylation functions in virtually all chromatin based biological processes including transcriptional regulation and DNA damage repair .

组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；

The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing , X inactivation and genomic imprinting .

组蛋白赖氨酸去甲基化酶有可能成为一个新的抗肿瘤治疗靶标。

Therefore , histone lysine demethylases may serve as a new target for anti-cancer therapy .

组蛋白赖氨酸去甲基化与基因调控

Histone Lysine Demethylation and Gene Regulation

健康人血非对称性二甲基精氨酸、DNA甲基化随增龄变化及与肾脏衰老的关系

The Age-related Changes of Asymmetric Dimethylarginine 、 DNA Methylation and the Relationship between Them and Kidney Aging

组蛋白的共价修饰包括赖氨酸的乙酰化、甲基化和精氨酸的甲基化等。

Chromatin covalent modification included acetylation and methylation of lysine and arginine .

目前关于蛋白质精氨酸甲基转移酶及其催化的精氨酸甲基化修饰在植物发育中的作用还没有任何报道。

However , little is known about the functions of histone arginine methylation in plants .

近年来随着更多的组蛋白赖氨酸甲基转移酶及作用蛋白的鉴定，对组蛋白赖氨酸甲基化的功能有了进一步认识。

The identification of more and more histone lysine methyltransferases and effector proteins in recent years has increased our understanding of the functions of histone lysine methylation .