栓剂

前列腺素E1栓剂治疗肺心病呼衰并肺动脉高压的近期疗效观察

Effects of prostaglandin E_1 suppository on pulmonary hypertension of patients with cor pulmonale complicated with respiratory failure during treatment

RP-HPLC法测定复方氧氟沙星栓剂中氧氟沙星和甲硝唑的含量

Determination of Ofloxacin and Metronidazole in Compoud of Ofloxacin Suppository by RP-HPLC

HPLC法测定复方氢化可的松栓剂中维生素E的含量

Determination of Vitamin E in Compound Hydrocortisone Suppository by HPLC

15-甲基前列腺素F（2α）缓释栓剂的研究

Studies on 15-methylprostaglandin f_ ( 2 α) sustained release suppositories

控释前列腺素E2栓剂用于50例促宫颈成熟和引产的临床观察

Clinical study on prostaglandin E_2 preparation for cervical ripening and labour induction in 50 cases

经对10批样品的测定表明，栓剂中没食子酸的最高含量为1.080mg／g，最低含量0.8051mg／g。

Among 10 samples the lowest content was 0 . 8051mg / g , the highest was 1 . 080mg / g.

RP-HPLC法测定优赛清栓剂中盐酸黄连素含量

RP-HPLC determination of berberine hydrochloride in You Sai Qing suppository

为探索直肠癌术前氟尿嘧啶（5－FU）辅助化疗更合理的给药途径，作者应用同位素￣（14）C标记的5－FU栓剂，经直肠腔内给药，进行了组织浓度和分布的测定。

More reasonable route of administration of 5-FU in rectal cancer therapy ,￣( 14 ) C-tagged 5-FU suppository intrarectal administration was studied experimentally .

方法分别以36型半合成脂肪酸酯、聚乙二醇（PEG）为基质，制备几种常用抗阴道感染药物的栓剂，测定相应的置换价。

METHOD Suppositories were prepared by using two different kinds of matrixes and the corresponding displacement values were determined .

重组人干扰素α2a直肠栓剂的研究

Study of Recombinant Human Alpha-2a-interferon Rectal Suppository

以乙醚-石油醚（1∶1）溶解栓剂，并用50%甲醇水溶液萃取，再经HPLC测定。

The Suppository was solved by ether : petroleum ether ( 1 ∶ 1 ), extracted by 50 % methanol aqueous solution , then determined by HPLC .

表明：AMI是由突然冠脉血栓性闭塞所致并可用溶栓剂或机械的方法使闭塞的冠脉再通。

This suggested that AMI was caused by sudden coronary occlusion of thrombus and could be opened by using emzyme or mechanical method .

为测试复方阴道栓剂（CG栓）疗效及毒性和刺激性。

Objective : To study the antibacterial effects in vitro and the acute toxicity and irritability of CG suppository .

研制了三种不同基质的苯巴比妥（phenobarbital，PBT）栓剂，并对其在家兔体内的药物动力学与市售片剂进行了比较。

Three phenobarbital suppositories were prepared and their pharmacokinetics were compared with that of phenobarbital tablet in rabbit .

目的：探讨控释前列腺素E2栓剂用于足月妊娠促宫颈成熟及引产的有效性及安全性。

Objective : To explore the efficacy and safety of Prostaglandin E_2 ( PGE2 ) used for cervical ripening and intermediate labour induction .

为了测定这两种栓剂的物理性状，对栓剂的融变时限、外形、色泽、重量差异、熔点范围、pH值、变形温度进行了测定和检查。

In order to determine the physics character of these two suppositories , the melt time , the shape , the color , the weight difference , the melting point , pH , transfiguration temperature were measured .

控释前列腺素E2栓剂普贝生用于足月引产的临床研究目的探讨控释前列腺素E2栓剂普贝生用于足月引产的有效性及安全性。

Clinical evaluation of propess for induction of term pregnancy Objective To explore the efficacy and safety of continuously released prostaglandin E_2 ( PGE_2 ) suppository-propess used for induction of term pregnancy .

结论：r-sk静脉溶栓再通率高，不良反应少，为一安全有效的溶栓剂。

Conclusion : China-made r-sk is a safe and effective thrombolytic agent .

本文用双抗体放射免疫法，测定了21例支气管哮喘和16例慢性支气管炎发作期空腹及用复方洋金花栓剂后血清胰多肽（PP）水平。

Serum pancreatic polypeptide ( PP ) both at fasting state and after giving compound datura stramonium suppository were measured by RIA in 21 cases of bronchial asthma and 16 cases of chronic bronchitis during attack .

目的急性心肌梗死（AMI）是心血管急症这一，链激酶（SK）、尿激酶（UK）同属第一代溶栓剂，在我国AMI临床治疗中应用广泛。

Objective Acute myocardial infarction ( AMI ) is an emergency of cardio-vascular system . streptokinase ( SK ) and urokinase ( UK ) are widely used in the treatment for AMI .

结果硝酸舍他康唑栓剂对白念珠菌和热带念珠菌引起SD大鼠念珠菌性阴道炎的治愈率为100%（5/5），停药2周后仍保持满意的治疗效果。

The efficacy was measured by fungi cultivation at the end of , 1 week and 2 weeks after treatment . Results The cure rate of sertaconazole suppositories in the treatment of vulvovaginal candidosis is 100 % .

第三代溶栓药物包括TNK-PA，STAR，rPA等以及正在研制的一些新型溶栓剂。

The third-generation thrombolytic agents are several types new thrombolytic agents being developed , including TNK-PA , STAR , rPA , and so on .

16,16二甲基Δ~2前列腺素E1甲基酯阴道栓剂（代号ONO802）用于终止早、中期妊娠共117例，76例早期妊娠的流产有效率为77.6%，完全流产率为50%；

A prostaglandin analogue 16 , 16-dimethyl trans - △ ~ 2-PGE_1 methyl ester pessary ( ONO-802 ) was used for the termination of the first and second trimester pregnancies in 117 cases .

方法以PEG400，PEG6000为基质，熔融法制备奥硝唑栓剂，采用紫外分光光度法测定其含量。

METHODS PEG400 , PEG6000 were used as suppository base and the drug concentration was determined by UV-spectrophotometry .

方法采用满因子分析设计法，以栓剂体外溶化时间为指标，选定处方中聚乙二醇（PEG）4000/PEG6000的比例和栓剂制备时水浴加热的温度作为考察因素。

Methods Using liquescent time of suppository in vitro as marker , full factor design method was used . The ratio of PEG 4000 / PEG 6000 in prescription and warm-up temperature of water bath were selected as observing factors .

方法：采用C18反相柱，以二甲基亚砜乙腈05%醋酸铵溶液（1∶14∶1）为流动相，456nm为检测波长，测定牛黄复方栓剂中胆红素的含量；

Method : C_ 18 column was used . The mobile phase was consisted of dimethylsulfoxide : acetonitrile : 0.5 % acetic ammonium ( 1 ∶ 1.4 ∶ 1 ) .

结论：溶栓治疗可使AMI患者凝血活性明显减弱，纤溶活性明显增强，但溶栓剂的作用时限短暂，监测PT、APTT、Fg等指标对预防出血有一定意义。

Conclusion : After thrombolytic therapy , the fibrinolytic activity was significantly increased , coagulative activity was significantly decreased . During thrombolytic therapy , monitoring PT , APTT , Fg can play a role for preventing bleeding complication .

重组人干扰素a（2a）栓剂对慢性盆腔结缔组织炎的疗效

And object and compare the curative effect between human recombinant interferon a2b effervescent tablet and human recombinant interferon a2b suppository . Curative Effect of rIFN-a_ ( 2a ) Suppository on Chronic Inflammation of Pelvic Connective Tissue

[结论]r-Sak能减轻SAP的病变程度和心肌损伤，可能具有治疗SAP及预防心肌损伤等并发症的作用，特异性溶栓剂的应用可能成为治疗SAP的新途径。

[ Conclusion ] : R-Sak can lighten the pathological changes of SAP rats , and alleviate myocardial damage following SAP . R-Sak is a promising agent for SAP therapy and the application of thrombolytic agents would be a new strategy for SAP therapy .

两组用药均为肛门栓剂，20d为一疗程，连用1～3个疗程。

Each group included 40 patients who were administered the respective medicine 20 days for one course of treatment , continued 1 ~ 3 courses of treatment .